Efficacy and Safety of Vitamin D in the Treatment of Asthma: An Overview of Systematic Reviews and Meta-Analyses
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By
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Liu, Yongxiu
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Lu, Jiaheng
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Li, Donghao
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Wang, Zhuang
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Zhang, Chi
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Li, Yuguo
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Liang, Shuang
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Yang, Haimiao
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Gao, Lei
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May 6, 2026
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Clinical Scorecard: Assessment of Vitamin D Supplementation for Asthma Management: A Comprehensive Review of Systematic Reviews and Meta-Analyses
At a Glance
| Category | Detail |
|---|
| Condition | Asthma |
| Key Mechanisms | Immune regulation and respiratory defense |
| Target Population | Patients with asthma |
| Care Setting | Clinical settings evaluating adjunctive treatments |
Key Highlights
- Vitamin D supplementation may reduce the risk of asthma exacerbations.
- Effects on asthma control, lung function, and inflammatory outcomes are limited or inconsistent.
- No significant increase in adverse events was observed.
- Evidence certainty varies, with many findings supported by low or very low certainty evidence.
- Substantial overlap among primary studies was noted.
Guideline-Based Recommendations
Diagnosis
Management
- Consider vitamin D supplementation as an adjunctive treatment for asthma.
Monitoring & Follow-up
Risks
- Caution due to heterogeneity and evidence uncertainty.
Patient & Prescribing Data
Patients with asthma considering adjunctive therapies.
Optimal dose, duration, and biomarker-guided supplementation strategies need further investigation.
Clinical Best Practices
- Evaluate the potential benefits of vitamin D supplementation on a case-by-case basis.
- Monitor for asthma exacerbations in patients receiving vitamin D supplementation.
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