Shortening of central venous catheter time in men with hematological and oncological diseases for prevention of central venous catheter-related bloodstream infections: a target-trial-emulation study - Scorecard - MDSpire

Shortening of central venous catheter time in men with hematological and oncological diseases for prevention of central venous catheter-related bloodstream infections: a target-trial-emulation study

  • By

  • Oliver Kriege

  • Boris Böll

  • Nicole Brüder

  • Nicola Giesen

  • Julia Lanznaster

  • Susanne Mertins

  • Antrea Minti

  • Jan-Hendrik Naendrup

  • Martin Schmidt-Hieber

  • Ruth Seggewiss-Bernhardt

  • Philipp Weber

  • Kai Wille

  • Jens Panse

  • Marcus Hentrich

  • Enrico Schalk

  • July 10, 2026

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Clinical Scorecard: Reducing Central Venous Catheter Duration in Male Patients with Hematological and Oncological Disorders to Mitigate the Risk of Catheter-Associated Bloodstream Infections: A Target-Trial-Emulation Analysis

At a Glance

CategoryDetail
ConditionCatheter-Associated Bloodstream Infections (CRBSI)
Key MechanismsCentral venous catheters (CVC) as a source of infection, with male sex identified as an independent risk factor.
Target PopulationMale patients with hematological and oncological disorders.
Care SettingHematology/Oncology clinical settings.

Key Highlights

  • Higher CRBSI rates observed in men compared to women with hematological malignancies.
  • Simulation of earlier CVC removal in men aimed to reduce CRBSI rates.
  • Registry-based RCT methodology used to emulate a randomized controlled trial.

Guideline-Based Recommendations

Diagnosis

  • CRBSI diagnosed based on AGIHO criteria, including differential time-to-positivity and pathogen detection.

Management

  • Consider earlier CVC removal in male patients to mitigate CRBSI risk.

Monitoring & Follow-up

  • Monitor CVC dwelling time and associated infection rates.

Risks

  • Male sex is an independent risk factor for CRBSI.

Patient & Prescribing Data

Patients with hematological malignancies requiring CVC.

Shortening CVC duration may help reduce CRBSI rates in male patients.

Clinical Best Practices

  • Utilize registry data for prospective analysis of CRBSI interventions.
  • Balance CVC duration against infection risk in male patients.

Related Resources & Content

Original Source(s)

Shortening of central venous catheter time in men with hematological and oncological diseases for prevention of central venous catheter-related bloodstream infections: a target-trial-emulation study

  • by Oliver Kriege, Boris Böll, Nicole Brüder, Nicola Giesen, Julia Lanznaster, Susanne Mertins, Antrea Minti, Jan-Hendrik Naendrup, Martin Schmidt-Hieber, Ruth Seggewiss-Bernhardt, Philipp Weber, Kai Wille, Jens Panse, Marcus Hentrich, Enrico Schalk

  • July 10, 2026

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