Characteristics in the uterine cavity microbiota of infertile women with hydrosalpinx or endometrial polyps revealed by shotgun metagenomics - Scorecard - MDSpire
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Analysis of Uterine Cavity Microbiota in Infertile Women with Hydrosalpinx or Endometrial Polyps through Shotgun Metagenomics

  • By

  • ShuZhen Li

  • Huifeng Zeng

  • Xiulin Wan

  • Zhiruo Chen

  • Xia Nong

  • Lisi Peng

  • Qingyang Li

  • Yuxia Wang

  • July 2, 2026

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Clinical Scorecard: Analysis of Uterine Cavity Microbiota in Infertile Women with Hydrosalpinx or Endometrial Polyps through Shotgun Metagenomics

At a Glance

CategoryDetail
ConditionInfertility due to Endometrial Polyps and Hydrosalpinx
Key MechanismsDysbiosis of uterine cavity microbiota impacting reproductive health
Target PopulationInfertile women under 38 years of age undergoing IVF or ICSI
Care SettingCenter for Reproductive Medicine

Key Highlights

  • Higher microbial alpha diversity in fertile controls compared to EM and HD groups
  • EM group showed dysbiosis with elevated pathogenic bacteria, particularly Streptococcus
  • HD group exhibited reduced microbial load and increased Streptococcus
  • Study identifies distinct microbial profiles for EM and HD
  • Microbiota may serve as a potential biomarker for infertility

Guideline-Based Recommendations

Diagnosis

  • Utilize shotgun metagenomic sequencing for comprehensive characterization of uterine microbiota

Management

  • Consider microbiota-targeted interventions for infertility associated with EM and HD

Monitoring & Follow-up

  • Assess microbial profiles in the uterine cavity for changes during treatment

Risks

  • Increased risk of infertility due to dysbiosis in EM and HD

Patient & Prescribing Data

Infertile women with EM or HD undergoing IVF or ICSI

Oral administration of doxycycline for chronic endometritis treatment

Clinical Best Practices

  • Conduct thorough screening for gynecological conditions prior to IVF or ICSI
  • Implement strict sterile conditions during sample collection

Related Resources & Content

Original Source(s)

Characteristics in the uterine cavity microbiota of infertile women with hydrosalpinx or endometrial polyps revealed by shotgun metagenomics

  • by ShuZhen Li, Huifeng Zeng, Xiulin Wan, Zhiruo Chen, Xia Nong, Lisi Peng, Qingyang Li, Yuxia Wang

  • July 2, 2026

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