Modulation of chemokine secretion and oxidative stress in vitro in thyroid cells after exposure to thiocyanate, nitrate, or perchlorate - Scorecard - MDSpire

Impact of Thiocyanate, Nitrate, and Perchlorate on Chemokine Release and Oxidative Stress in Thyroid Cells In Vitro

  • By

  • Alessia Greco

  • Francesca Coperchini

  • Elena Franchi

  • Marco Denegri

  • Laura Croce

  • Marsida Teliti

  • Vincenzo Marotta

  • Flavia Magri

  • Giuseppina De Marco

  • Eleonora Ferrarini

  • Luisa Pignata

  • Patrizia Agretti

  • Massimo Tonacchera

  • Mario Rotondi

  • May 22, 2026

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Clinical Scorecard: Impact of Thiocyanate, Nitrate, and Perchlorate on Chemokine Release and Oxidative Stress in Thyroid Cells In Vitro

At a Glance

CategoryDetail
ConditionThyroid disruption and potential tumor promotion
Key MechanismsInhibition of iodide uptake, modulation of oxidative stress, and chemokine secretion
Target PopulationIndividuals exposed to perchlorate, nitrate, and thiocyanate
Care SettingIn vitro studies using human thyroid cells

Key Highlights

  • Thiocyanate reduced viability in TPC-1 cells at high doses.
  • Perchlorate induced a biphasic increase in ROS production in normal human thyroid cells.
  • Thiocyanate consistently increased CXCL8 secretion in normal and cancer thyroid cells.
  • Nitrate and perchlorate had minimal effects on chemokine expression.
  • CXCL10 protein was undetectable despite modulation of its mRNA expression.

Guideline-Based Recommendations

Diagnosis

  • Monitor exposure to thyroid disruptors in at-risk populations.

Management

  • Consider the impact of environmental factors on thyroid health.

Monitoring & Follow-up

  • Assess chemokine levels and oxidative stress markers in thyroid patients.

Risks

  • Increased risk of thyroid cancer associated with exposure to thiocyanate, nitrate, and perchlorate.

Patient & Prescribing Data

Patients with potential exposure to thyroid disruptors.

Focus on reducing exposure to environmental thyroid disruptors.

Clinical Best Practices

  • Evaluate thyroid function in patients with known exposure to environmental disruptors.
  • Implement strategies to minimize exposure to perchlorate, nitrate, and thiocyanate.

Related Resources & Content

Original Source(s)

Modulation of chemokine secretion and oxidative stress in vitro in thyroid cells after exposure to thiocyanate, nitrate, or perchlorate

  • by Alessia Greco, Francesca Coperchini, Elena Franchi, Marco Denegri, Laura Croce, Marsida Teliti, Vincenzo Marotta, Flavia Magri, Giuseppina De Marco, Eleonora Ferrarini, Luisa Pignata, Patrizia Agretti, Massimo Tonacchera, Mario Rotondi

  • May 22, 2026

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