Effects of ketogenic diet therapy in outpatient anti epileptic drug cost reduction and parental satisfaction among children with intractable epilepsy - Scorecard - MDSpire

Impact of Ketogenic Diet Therapy on Reducing Outpatient Anti-Epileptic Medication Costs and Enhancing Parental Satisfaction in Children with Drug-Resistant Epilepsy

  • By

  • Achmad Rafli

  • Setyo Handryastuti

  • Amanda Soebadi

  • Dara Ninggar Santoso

  • Indira Rahmawati

  • Ryan Pramana

  • Rahadian Ramadhan

  • Clifford Peter Anthony

  • Irawan Mangunatmadja

  • July 17, 2026

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Clinical Scorecard: Impact of Ketogenic Diet Therapy on Reducing Outpatient Anti-Epileptic Medication Costs and Enhancing Parental Satisfaction in Children with Drug-Resistant Epilepsy

At a Glance

CategoryDetail
ConditionDrug-Resistant Epilepsy
Key MechanismsKetogenic diet therapy alters neural metabolism and excitability, potentially reducing seizure frequency.
Target PopulationChildren aged 5–18 years with drug-resistant epilepsy.
Care SettingOutpatient setting in a general hospital.

Key Highlights

  • 21.8% reduction in outpatient anti-epileptic drug costs after 6 months of ketogenic diet therapy.
  • Statistically significant cost reduction of Rp 3,757,812 (approximately 235 US$).
  • Parental satisfaction with ketogenic diet therapy was evaluated through surveys.

Guideline-Based Recommendations

Diagnosis

  • Drug-resistant epilepsy defined as persistent seizures despite at least two tolerated anti-epileptic drugs.

Management

  • Consider ketogenic diet therapy as an alternative treatment for drug-resistant epilepsy.

Monitoring & Follow-up

  • Evaluate seizure frequency and parental satisfaction during ketogenic diet therapy.

Risks

  • Potential concerns regarding the cost and implementation of ketogenic diet therapy.

Patient & Prescribing Data

Children with drug-resistant epilepsy aged 5–18 years.

Incorporating ketogenic diet therapy can lead to significant financial savings in outpatient anti-epileptic medication costs.

Clinical Best Practices

  • Implement ketogenic diet therapy in a structured outpatient setting.
  • Provide parental education and resources for meal preparation.

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