Calcium signaling in psoriasis: from pathogenesis to therapeutic opportunities
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By
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Y. X. Chen
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D. X. Zhuo
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F. F. Wang
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July 15, 2026
Clinical Scorecard: Calcium Signaling in Psoriasis: Insights into Pathogenesis and Potential Treatment Strategies
At a Glance
| Category | Detail |
|---|
| Condition | Psoriasis |
| Key Mechanisms | Dysregulation of calcium signaling in keratinocytes and immune cells, particularly involving the IL-23/IL-17 inflammatory axis and SOCE. |
| Target Population | Individuals with psoriasis. |
| Care Setting | Dermatology and immunology clinics. |
Key Highlights
- Calcium signaling plays a dual role in psoriasis, regulating both keratinocyte differentiation and immune cell activation.
- The IL-23/IL-17 axis is central to the pathogenesis of psoriasis.
- SOCE is a critical mechanism for calcium influx in immune cells, influencing Th17 cell differentiation and function.
- Compartment-specific calcium dysregulation may contribute to the pathogenesis of psoriasis.
- Therapeutic strategies targeting calcium signaling are being explored.
Guideline-Based Recommendations
Diagnosis
- Diagnosis of psoriasis is based on clinical evaluation and history.
Management
- Consider therapies targeting calcium signaling pathways.
Monitoring & Follow-up
- Monitor for signs of inflammation and skin barrier function.
Risks
- Potential for exacerbation of symptoms due to immune dysregulation.
Patient & Prescribing Data
Patients diagnosed with psoriasis.
Emerging therapies may focus on modulating calcium signaling to restore balance in keratinocyte and immune cell function.
Clinical Best Practices
- Integrate assessment of calcium signaling in the management of psoriasis.
- Consider the role of immune dysregulation in treatment planning.
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