Noncanonical NF-κB pathway driven inflammation across multiple cellular compartments identifies NIK as a therapeutic target for inflammatory bowel disease - Scorecard - MDSpire

Noncanonical NF-κB pathway driven inflammation across multiple cellular compartments identifies NIK as a therapeutic target for inflammatory bowel disease

  • By

  • Hao Xu

  • Dun Li

  • Jie Liang

  • Nathan Adamson

  • Alexis Scherl

  • Luli Zou

  • Crystal Hu

  • Elaine E. Storm

  • Christian B. Cox

  • Adam Johnson

  • Mary E. Keir

  • Hua Zhang

  • Saiyu Hang

  • June 9, 2026

  • 0 min

Share

Clinical Scorecard: Targeting NIK in the Noncanonical NF-κB Pathway Reveals Inflammatory Mechanisms in Diverse Cellular Compartments Relevant to Inflammatory Bowel Disease

At a Glance

CategoryDetail
Condition
Key Mechanisms
Target Population
Care SettingPreclinical models

Key Highlights

    Guideline-Based Recommendations

    Diagnosis

      Management

        Monitoring & Follow-up

          Risks

            Patient & Prescribing Data

            Clinical Best Practices

              Related Resources & Content

              Original Source(s)

              Noncanonical NF-κB pathway driven inflammation across multiple cellular compartments identifies NIK as a therapeutic target for inflammatory bowel disease

              • by Hao Xu, Dun Li, Jie Liang, Nathan Adamson, Alexis Scherl, Luli Zou, Crystal Hu, Elaine E. Storm, Christian B. Cox, Adam Johnson, Mary E. Keir, Hua Zhang, Saiyu Hang

              • June 9, 2026

              Related Content

              The role of a multidisciplinary approach in the early and differential diagnosis of inflammatory bowel disease–related spondyloarthritis: insights from a cross-sectional study

              Mortality trends from colorectal pathologies in the United States (1999–2020): a retrospective cohort study using CDC WONDER

              Deep learning-based quantitative histopathology of endoscopic biopsies in Crohn’s disease: a retrospective cross-sectional validation study