Beyond identity categories: chronotype and mental health as correlates of sleep quality in transgender and gender-diverse adults - Scorecard - MDSpire

Beyond identity categories: chronotype and mental health as correlates of sleep quality in transgender and gender-diverse adults

  • By

  • Paolo Meneguzzo

  • Alessio A. Gugliotta

  • Angela Favaro

  • Sara Montagnese

  • Marina Bonato

  • Alberto Scala

  • Marina Miscioscia

  • Andrea Garolla

  • July 3, 2026

  • 0 min

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Clinical Scorecard: Exploring the Role of Chronotype and Mental Health in Sleep Quality Among Transgender and Gender-Diverse Individuals

At a Glance

CategoryDetail
ConditionSleep disturbance among transgender and gender-diverse individuals
Key MechanismsCircadian preference, mental health-related quality of life, gender-affirming hormone therapy
Target PopulationTransgender and gender-diverse adults
Care SettingSpecialized gender clinic

Key Highlights

  • Poor sleep quality is highly prevalent among transgender and gender-diverse adults.
  • Chronotype and mental health-related quality of life are the strongest correlates of sleep quality.
  • Eveningness is associated with poorer sleep quality, particularly among individuals receiving gender-affirming hormone therapy.
  • No association was found between duration of hormone therapy and sleep quality.
  • Sleep disturbances may reflect multidimensional vulnerability rather than identity-specific effects.

Guideline-Based Recommendations

Diagnosis

  • Utilize the Pittsburgh Sleep Quality Index (PSQI) for assessing sleep quality.

Management

  • Consider mental health-related quality of life in managing sleep disturbances.

Monitoring & Follow-up

  • Monitor sleep quality in relation to chronotype and GAHT status.

Risks

  • Identify psychological distress as a contributing factor to sleep disturbances.

Patient & Prescribing Data

Transgender and gender-diverse adults attending a specialized gender clinic.

Current gender-affirming hormone therapy is associated with poorer sleep quality, particularly in those with evening chronotype.

Clinical Best Practices

  • Assess chronotype and mental health when evaluating sleep quality in TGD individuals.
  • Address psychological distress as part of the treatment plan for sleep disturbances.

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