Beyond identity categories: chronotype and mental health as correlates of sleep quality in transgender and gender-diverse adults
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By
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Paolo Meneguzzo
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Alessio A. Gugliotta
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Angela Favaro
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Sara Montagnese
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Marina Bonato
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Alberto Scala
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Marina Miscioscia
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Andrea Garolla
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July 3, 2026
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Clinical Scorecard: Exploring the Role of Chronotype and Mental Health in Sleep Quality Among Transgender and Gender-Diverse Individuals
At a Glance
| Category | Detail |
| Condition | Sleep disturbance among transgender and gender-diverse individuals |
| Key Mechanisms | Circadian preference, mental health-related quality of life, gender-affirming hormone therapy |
| Target Population | Transgender and gender-diverse adults |
| Care Setting | Specialized gender clinic |
Key Highlights
- Poor sleep quality is highly prevalent among transgender and gender-diverse adults.
- Chronotype and mental health-related quality of life are the strongest correlates of sleep quality.
- Eveningness is associated with poorer sleep quality, particularly among individuals receiving gender-affirming hormone therapy.
- No association was found between duration of hormone therapy and sleep quality.
- Sleep disturbances may reflect multidimensional vulnerability rather than identity-specific effects.
Guideline-Based Recommendations
Diagnosis
- Utilize the Pittsburgh Sleep Quality Index (PSQI) for assessing sleep quality.
Management
- Consider mental health-related quality of life in managing sleep disturbances.
Monitoring & Follow-up
- Monitor sleep quality in relation to chronotype and GAHT status.
Risks
- Identify psychological distress as a contributing factor to sleep disturbances.
Patient & Prescribing Data
Transgender and gender-diverse adults attending a specialized gender clinic.
Current gender-affirming hormone therapy is associated with poorer sleep quality, particularly in those with evening chronotype.
Clinical Best Practices
- Assess chronotype and mental health when evaluating sleep quality in TGD individuals.
- Address psychological distress as part of the treatment plan for sleep disturbances.
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