Exploring the Role of Chronotype and Mental Health in Sleep Quality Among Transgender and Gender-Diverse Individuals
By
Paolo Meneguzzo
Alessio A. Gugliotta
Angela Favaro
Sara Montagnese
Marina Bonato
Alberto Scala
Marina Miscioscia
Andrea Garolla
July 3, 2026
Clinical Scorecard: Exploring the Role of Chronotype and Mental Health in Sleep Quality Among Transgender and Gender-Diverse Individuals
At a Glance
Category Detail
Condition Sleep disturbance among transgender and gender-diverse individuals
Key Mechanisms Circadian preference, mental health-related quality of life, gender-affirming hormone therapy
Target Population Transgender and gender-diverse adults
Care Setting Specialized gender clinic
Key Highlights
Poor sleep quality is highly prevalent among transgender and gender-diverse adults. Chronotype and mental health-related quality of life are the strongest correlates of sleep quality. Eveningness is associated with poorer sleep quality, particularly among individuals receiving gender-affirming hormone therapy. No association was found between duration of hormone therapy and sleep quality. Sleep disturbances may reflect multidimensional vulnerability rather than identity-specific effects.
Guideline-Based Recommendations
Diagnosis
Utilize the Pittsburgh Sleep Quality Index (PSQI) for assessing sleep quality.
Management
Consider mental health-related quality of life in managing sleep disturbances.
Monitoring & Follow-up
Monitor sleep quality in relation to chronotype and GAHT status.
Risks
Identify psychological distress as a contributing factor to sleep disturbances.
Patient & Prescribing Data
Transgender and gender-diverse adults attending a specialized gender clinic.
Current gender-affirming hormone therapy is associated with poorer sleep quality, particularly in those with evening chronotype.
Clinical Best Practices
Assess chronotype and mental health when evaluating sleep quality in TGD individuals. Address psychological distress as part of the treatment plan for sleep disturbances.
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