Case report: When Behçet’s disease meets multizonal outer retinopathy and retinal pigment epitheliopathy: longitudinal multimodal imaging of an overlap phenotype

Category	Detail
Condition
Key Mechanisms	Chronic systemic vasculitis with ocular inflammation and retinal dysfunction, emphasizing the role of immune-mediated processes.
Target Population
Care Setting

37-year-old male with unilateral, painless, progressive vision loss and recurrent oral ulcers.
Multimodal imaging revealed bilateral outer retinopathy and retinal vasculitis, with specific imaging findings detailed.
Diagnosis of MORR complicated by Behçet’s uveitis established through comprehensive imaging.
Systemic treatment initiated with corticosteroids and cyclosporine, with rationale provided.
Longitudinal follow-up showed stability of lesions after treatment, with specific imaging results noted.

Utilize multimodal imaging (OCT, FAF, FFA) for accurate diagnosis of retinal conditions.
Consider Behçet’s disease in patients with recurrent oral ulcers and ocular symptoms.

Initiate systemic treatment with corticosteroids and immunosuppressants for acute progression, detailing the treatment protocol.
Monitor visual acuity and retinal imaging for treatment response, specifying the imaging techniques.

Regular follow-up with OCT and FAF to assess retinal changes, emphasizing the importance of these modalities.
Monitor for potential progression of retinal lesions, with examples of what to look for.

Vision loss due to retinal vasculitis and outer retinopathy, detailing the mechanisms involved.
Potential side effects from systemic immunosuppressive therapy, with examples provided.

Oral corticosteroids combined with cyclosporine showed favorable response in this case, with alternative treatments discussed.

Maintain vigilance for concurrent outer retinopathy in Behçet’s uveitis, with examples of imaging findings.
Employ comprehensive imaging techniques (OCT, FAF, FFA) for diagnosis and monitoring, detailing their specific roles.

Clinical Scorecard: Case Study: Documenting the Intersection of Behçet’s Disease with Multizonal Outer Retinopathy and Retinal Pigment Epitheliopathy through Longitudinal Multimodal Imaging