Physician-led versus questionnaire-based psychosocial screening in adults with high-grade glioma: a cluster-randomized controlled trial (GLIOPT) - Scorecard - MDSpire
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Physician-led versus questionnaire-based psychosocial screening in adults with high-grade glioma: a cluster-randomized controlled trial (GLIOPT)
Clinical Scorecard: Comparison of Physician-led and Questionnaire-based Psychosocial Assessments in Adults with High-Grade Glioma: Results from a Cluster-Randomized Controlled Trial (GLIOPT)
At a Glance
Category
Detail
Condition
High-grade glioma (glioblastoma, gliosarcoma, anaplastic astrocytoma WHO grade III, anaplastic oligodendroglioma WHO grade III)
Key Mechanisms
High symptom burden including neurological deficits, neurocognitive decline, depression, and anxiety requiring psychosocial support
Target Population
Adults (≥18 years) diagnosed with high-grade glioma able to provide informed consent and understand German questionnaires
Care Setting
Outpatient neuro-oncological care in certified neuro-oncological centers
Key Highlights
High-grade glioma patients experience significant neurocognitive and psychiatric symptoms necessitating psychosocial assessment and support.
GLIOPT trial compared physician-led psychosocial distress assessment during consultations versus questionnaire-based screening using the Distress Thermometer.
Psychosocial screening instruments often lack adaptation for neurocognitive deficits common in high-grade glioma patients.
Guideline-Based Recommendations
Diagnosis
Regular psycho-oncological screening recommended for high-grade glioma patients to identify unmet psychosocial needs.
Use validated tools such as the NCCN Distress Thermometer adapted for brain tumor patients.
Management
Integrate psychosocial distress assessment into doctor-patient consultations to potentially improve identification of patients needing support.
Provide timely psycho-oncological and social-legal support based on urgency within days to two weeks.
Monitoring & Follow-up
Assess psychosocial distress at baseline, post-consultation, and follow-up (e.g., 3 months) to monitor patient needs and response to interventions.
Risks
Inadequate psychosocial screening may lead to under-recognition of distress and unmet support needs.
Neurocognitive deficits may impair patient self-reporting, requiring adapted assessment approaches.
Patient & Prescribing Data
Adults with high-grade glioma undergoing outpatient neuro-oncological care
Psychosocial care provision should be individualized based on distress assessment integrated into clinical consultations or validated questionnaires, considering neurocognitive impairments.
Clinical Best Practices
Incorporate simple, targeted psychosocial screening questions into routine doctor-patient consultations to enhance detection of distress.
Use validated distress screening tools like the NCCN Distress Thermometer adapted for brain tumor patients.
Ensure psycho-oncological support services are accessible and responsive within a short timeframe after identification of distress.
Consider neurocognitive deficits when selecting or adapting psychosocial assessment instruments.
Obtain informed consent and support patients in questionnaire completion as needed.
by Mirjam Renovanz, Melina Hippler, Robert Kuchen, Lorenz Doerner, David Rieger, Joachim P. Steinbach, Michael W. Ronellenfitsch, Martin Voss, Almuth F. Kessler, Vera Nickl, Martin Misch, Julia Sophie Onken, Marion Rapp, Minou Nadji-Ohl, Marcus Mehlitz, Jürgen Meixensberger, Michael Karl Fehrenbach, Naureen Keric, Florian Ringel, Jan Coburger, Carolin Weiß Lucas, Jens Wehinger, Friederike Schmidt-Graf, Jens Gempt, Marcos Tatagiba, Ghazaleh Tabatabai, Melanie Schranz, Susanne Singer
