Patient-facing diabetic foot information from large language models: a domain- and source-balanced prompt framework for public-interface benchmarking - Scorecard - MDSpire

Evaluating Patient-Centric Diabetic Foot Information Generated by Large Language Models: A Framework for Balanced Prompt Design and Public Interface Assessment

  • By

  • Yang Wen

  • Liyuan Chen

  • Jiaping Lan

  • Lin Chen

  • Lei Li

  • July 21, 2026

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Clinical Scorecard: Evaluating Patient-Centric Diabetic Foot Information Generated by Large Language Models: A Framework for Balanced Prompt Design and Public Interface Assessment

At a Glance

CategoryDetail
ConditionDiabetes-related foot disease
Key MechanismsRecognition of neuropathic risk, ulceration, infection, ischemia, offloading needs, and recurrence risk.
Target PopulationIndividuals with diabetes
Care SettingPublicly accessible large language models for patient education

Key Highlights

  • Developed a 24-item benchmark prompt set for evaluating LLM outputs.
  • Significant differences in response quality observed across five LLMs.
  • Grok 4.3 achieved the highest scores for quality metrics.
  • No responses met all predefined readability targets.
  • Responses showed limited visible transparency and inadequate readability.

Guideline-Based Recommendations

Diagnosis

  • Timely recognition of neuropathic risk and ulceration.

Management

  • Emphasize prevention, early recognition, and multidisciplinary management.

Monitoring & Follow-up

  • Structured follow-up and escalation of care for suspected complications.

Risks

  • Potential for misinterpretation of LLM-generated information without clinician oversight.

Patient & Prescribing Data

Patients with diabetes at risk for foot disease.

Patient-facing information must be practical, understandable, and actionable.

Clinical Best Practices

  • Utilize a domain- and source-balanced prompt framework for patient education.
  • Ensure clinician oversight when using LLM-generated information for decision-making.

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