Impact of Shenfu Injection on 28-Day Mortality Rates in Critically Ill Sepsis Patients: A Retrospective Cohort Analysis with Propensity Score Matching - Scorecard - MDSpire

Impact of Shenfu Injection on 28-Day Mortality Rates in Critically Ill Sepsis Patients: A Retrospective Cohort Analysis with Propensity Score Matching

  • By

  • Jinrong Li

  • Yunxin Deng

  • Yanxia Huang

  • Liya Gao

  • Congjie Zhu

  • Haiming Jiang

  • Fengyong Yang

  • Yufeng Chu

  • Ranran Li

  • Mei Meng

  • February 11, 2026

  • 0 min

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Clinical Scorecard: Impact of Shenfu Injection on 28-Day Mortality Rates in Critically Ill Sepsis Patients: A Retrospective Cohort Analysis with Propensity Score Matching

At a Glance

CategoryDetail
ConditionSepsis
Key MechanismsSystemic vasodilatation, hypovolemia, myocardial dysfunction, microcirculatory abnormalities, coagulation abnormalities, metabolic dysfunction.
Target PopulationAdult patients diagnosed with sepsis 2.0 and 3.0 in ICUs.
Care SettingIntensive Care Units (ICUs)

Key Highlights

  • Shenfu Injection (SFI) is derived from traditional Chinese medicine.
  • SFI may protect organ function and reduce inflammation in sepsis.
  • Inconsistent results regarding 28-day mortality in sepsis patients have been reported.
  • The study utilized propensity score matching to address confounding factors.
  • Adverse effects of SFI were monitored during a 28-day follow-up.

Guideline-Based Recommendations

Diagnosis

  • Early identification of sepsis is crucial.

Management

  • Standard care includes antimicrobials, fluid resuscitation, and vasoactive agents.

Monitoring & Follow-up

  • Monitor for adverse events and severe adverse events during treatment.

Risks

  • Potential adverse effects include nausea, vomiting, and allergic reactions.

Patient & Prescribing Data

Adult ICU patients diagnosed with sepsis.

SFI may be considered as an adjunct therapy alongside standard care.

Clinical Best Practices

  • Implement early sepsis management protocols.
  • Consider traditional Chinese medicine as a complementary approach.
  • Utilize propensity score matching in observational studies to reduce bias.

References

Original Source(s)

Impact of Shenfu Injection on 28-Day Mortality Rates in Critically Ill Sepsis Patients: A Retrospective Cohort Analysis with Propensity Score Matching

  • by Jinrong Li, Yunxin Deng, Yanxia Huang, Liya Gao, Congjie Zhu, Haiming Jiang, Fengyong Yang, Yufeng Chu, Ranran Li, Mei Meng

  • February 11, 2026

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