The Relationship Between Glycated Hemoglobin Levels and In-Stent Restenosis After Percutaneous Coronary Intervention in Patients with Coronary Artery Disease - Scorecard - MDSpire

The Relationship Between Glycated Hemoglobin Levels and In-Stent Restenosis After Percutaneous Coronary Intervention in Patients with Coronary Artery Disease

  • By

  • Yuyang Lei

  • Ping Jin

  • Hui Liu

  • Lin Su

  • Di Wu

  • Chenxi Sun

  • Haoyu Wu

  • Juan Zhou

  • Chen Wang

  • April 23, 2026

  • 0 min

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Clinical Scorecard: The Relationship Between Glycated Hemoglobin Levels and In-Stent Restenosis After Percutaneous Coronary Intervention in Patients with Coronary Artery Disease

At a Glance

CategoryDetail
Condition
Key MechanismsHigher HbA1c levels linked to increased ISR risk through inflammation, oxidative stress, and VSMC proliferation, as evidenced by study findings.
Target Population
Care Setting

Key Highlights

  • 20.72% of CAD patients post-PCI developed ISR.
  • Higher HbA1c levels significantly associated with increased ISR risk (OR: 1.18, 95% CI: 1.09–1.27).
  • Threshold effect observed at HbA1c level of 7.8%.

Guideline-Based Recommendations

Diagnosis

    Management

    • Monitor HbA1c levels in CAD patients post-PCI to assess ISR risk, aiming for levels <6.5%.

    Monitoring & Follow-up

      Risks

        Patient & Prescribing Data

        6297 CAD patients post-PCI.

        Elevated HbA1c levels indicate a need for improved glycemic control to reduce ISR risk.

        Clinical Best Practices

        • Implement routine HbA1c monitoring for CAD patients undergoing PCI, supported by recent studies.
        • Consider glycemic control strategies to mitigate ISR risk, referencing current guidelines.

        References

        Original Source(s)

        The Relationship Between Glycated Hemoglobin Levels and In-Stent Restenosis After Percutaneous Coronary Intervention in Patients with Coronary Artery Disease

        • by Yuyang Lei, Ping Jin, Hui Liu, Lin Su, Di Wu, Chenxi Sun, Haoyu Wu, Juan Zhou, Chen Wang

        • April 23, 2026

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