The evolving role of regulatory T cells in pulmonary diseases: immunomodulatory mechanisms and translational directions revealed by bibliometric analysis - Scorecard - MDSpire

The evolving role of regulatory T cells in pulmonary diseases: immunomodulatory mechanisms and translational directions revealed by bibliometric analysis

  • By

  • Qiuxia Wang

  • Jianfeng Jiang

  • Huici Yao

  • Ying Zhu

  • June 9, 2026

  • 0 min

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Clinical Scorecard: The Changing Function of Regulatory T Cells in Lung Diseases: Insights into Immunomodulatory Mechanisms and Future Directions from Bibliometric Analysis

At a Glance

CategoryDetail
ConditionPulmonary Diseases
Key MechanismsRegulatory T cells (Tregs) and their role in immune homeostasis and disease progression.
Target PopulationPatients with various pulmonary diseases, including asthma, COPD, and lung cancer.
Care SettingResearch and clinical settings focusing on immunology and respiratory medicine.

Key Highlights

  • Tregs are crucial for maintaining pulmonary immune balance.
  • Dysregulation of Tregs is linked to poor outcomes in lung diseases.
  • Research on Tregs has evolved into multiple interconnected hotspots.
  • China has emerged as the leading country in Treg research since 2021.
  • Emerging therapeutic strategies include targeting Tregs and the tumor microenvironment.

Guideline-Based Recommendations

Diagnosis

  • Assess Treg levels and function in patients with pulmonary diseases.

Management

  • Consider immunotherapy targeting Tregs in treatment plans for lung diseases.

Monitoring & Follow-up

  • Monitor Treg populations and their functional status in patients.

Risks

  • Dysregulation of Tregs can lead to exacerbation of pulmonary diseases.

Patient & Prescribing Data

Individuals with chronic inflammatory lung diseases and cancer.

Targeting Tregs may offer new avenues for precision immunotherapy.

Clinical Best Practices

  • Utilize bibliometric analysis for understanding research trends in Treg studies.
  • Incorporate findings on Tregs into clinical research and practice.

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