Improving Empiric Antibiotic Selection for Patients With Cancer Hospitalized With Infection: Secondary - Scorecard - MDSpire

Improving Empiric Antibiotic Selection for Patients With Cancer Hospitalized With Infection: Secondary

  • By

  • Shruti K. Gohil

  • Taliser R. Avery

  • Ken Kleinman

  • Edward Septimus

  • Amarah Mauricio

  • Kenneth E. Sands

  • Neha Varma

  • Selsebil Sljivo

  • Kaleb Roemer

  • William S. Cooper

  • Russell E. Poland

  • Robert A. Weinstein

  • Samir M. Fakhry

  • Jeffrey Guy

  • Julia Moody

  • Micaela H. Coady

  • Kim N. Smith-Sells

  • Mary K. Hayden

  • David W. Kubiak

  • Chenette Burks

  • Richard Platt

  • Susan S. Huang

  • Meghan A. Baker

  • June 10, 2026

  • 0 min

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Clinical Scorecard: Enhancing Empiric Antibiotic Choices for Hospitalized Cancer Patients with Infections: A Secondary Analysis

At a Glance

CategoryDetail
Condition
Key MechanismsUse of computerized provider order entry (CPOE) prompts to recommend standard-spectrum antibiotics based on estimated risk of multidrug-resistant organisms (MDRO), integrated into clinical workflows.
Target Population
Care Setting

Key Highlights

  • Antibiotic stewardship bundle reduced extended-spectrum antibiotic selection.
  • CPOE prompts triggered for patients with less than 10% risk of MDRO infection.
  • No exclusion for patients with hematologic or solid organ malignancies.
  • Documentation of indication was mandatory for all antibiotic orders.
  • Routine stewardship activities included de-escalation based on microbiologic results.
  • Emphasized the importance of de-escalation based on microbiologic results.

Guideline-Based Recommendations

Diagnosis

    Management

    • Use standard-spectrum antibiotics when MDRO risk is low (<10%), such as amoxicillin or cefazolin.

    Monitoring & Follow-up

      Risks

        Patient & Prescribing Data

        Judicious use of antibiotics is critical due to the risk of resistance and adverse effects, particularly in cancer patients who may have compromised immune systems.

        Clinical Best Practices

        • Implement CPOE prompts for antibiotic selection.
        • Require documentation of indication for antibiotic orders.
        • Educate clinicians on national guidelines and personalized feedback.
        • Regularly review antibiotic prescribing patterns to enhance stewardship.

        Related Resources & Content

        Original Source(s)

        Improving Empiric Antibiotic Selection for Patients With Cancer Hospitalized With Infection: Secondary

        • by Shruti K. Gohil, Taliser R. Avery, Ken Kleinman, Edward Septimus, Amarah Mauricio, Kenneth E. Sands, Neha Varma, Selsebil Sljivo, Kaleb Roemer, William S. Cooper, Russell E. Poland, Robert A. Weinstein, Samir M. Fakhry, Jeffrey Guy, Julia Moody, Micaela H. Coady, Kim N. Smith-Sells, Mary K. Hayden, David W. Kubiak, Chenette Burks, Richard Platt, Susan S. Huang, Meghan A. Baker

        • June 10, 2026

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