Clinical efficacy and safety of subtotal resection of adenomyotic lesions based on the Kishi classification: a retrospective case series study - Scorecard - MDSpire

Clinical efficacy and safety of subtotal resection of adenomyotic lesions based on the Kishi classification: a retrospective case series study

  • By

  • Zhenyue Qin

  • Dan Song

  • Zhiyong Dong

  • Bingying Lu

  • Weiwei Wei

  • Jiming Chen

  • June 11, 2026

  • 0 min

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Clinical Scorecard: Efficacy and Safety of Subtotal Resection for Adenomyotic Lesions According to Kishi Classification: A Retrospective Case Series Analysis

At a Glance

CategoryDetail
ConditionSevere Adenomyosis
Key MechanismsSubtotal resection of adenomyotic lesions combined with sequential LNG-IUS and GnRH-a therapy.
Target PopulationPatients with severe adenomyosis desiring uterine preservation and not seeking future fertility.
Care SettingDepartment of Gynecology, Changzhou Second People’s Hospital Affiliated to Nanjing Medical University.

Key Highlights

  • Significant improvements in dysmenorrhea severity, menstrual blood loss, hemoglobin levels, CA125 levels, and uterine volume post-surgery.
  • No serious adverse events reported during the study.
  • All patients successfully underwent surgery with a follow-up period of 12 months.
  • Only one case of mild CA125 elevation and one case of intrauterine device displacement noted.
  • No disease progression observed in any patient.

Guideline-Based Recommendations

Diagnosis

  • Utilize Kishi classification based on MRI for guiding clinical treatment.

Management

  • Perform subtotal resection of adenomyotic lesions followed by LNG-IUS and GnRH-a therapy.

Monitoring & Follow-up

  • Monitor dysmenorrhea severity, menstrual blood loss, hemoglobin concentration, and CA125 levels postoperatively.

Risks

  • Potential for postoperative recurrence of adenomyosis.

Patient & Prescribing Data

34 patients with severe adenomyosis.

Combined surgical and pharmacological approach showed significant clinical improvements.

Clinical Best Practices

  • Thorough excision of adenomyotic lesions during surgery.
  • Sequential administration of LNG-IUS and GnRH-a postoperatively to reduce recurrence.

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