Case Report: Penile malignant melanoma: insights from a three-case series and literature review on diagnosis and management
By
Xiaoxiao Xu
Xiaolong Hou
Hongze Li
Yiming Chen
Bohao Jiang
Hao Zhang
July 17, 2026
Clinical Scorecard: Case Series Analysis: Insights into Diagnosis and Management of Penile Malignant Melanoma from Three Cases and a Literature Review
At a Glance
Category Detail
Condition Penile Malignant Melanoma Key Mechanisms Aggressive mucosal melanoma with high mortality rates and late diagnosis. Target Population Middle-aged and older men. Care Setting Clinical management of rare malignancies.
Key Highlights
Penile melanoma accounts for less than 2% of all penile tumors. Surgical treatment is the primary management option. Adjuvant therapies include chemotherapy and radiotherapy. Emerging treatments include immune checkpoint inhibitors and targeted therapies. Personalized management strategies are essential. Guideline-Based Recommendations
Diagnosis
Pathological diagnosis confirmed through histopathological examination. Management
Surgical resection is the primary treatment, with options for local or partial penectomy. Monitoring & Follow-up
Regular imaging and clinical follow-up are necessary to assess for recurrence. Risks
High mortality rates associated with late diagnosis and disease progression. Patient & Prescribing Data
Patients diagnosed with primary penile melanoma.
Chemotherapy may be used post-surgery, but treatment tolerance varies.
Clinical Best Practices
Ensure complete resection with negative margins during surgery. Consider genetic testing for personalized treatment options. Integrate systemic therapies based on emerging evidence. Related Resources & Content
