Case Report: A rare case of esophageal squamous cell carcinoma with metastases to the pancreas and stomach
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By
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Yuhang Lv
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Yanting Jiang
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Kaiyuan Hui
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Xiaodong Jiang
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June 11, 2026
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Clinical Scorecard: Uncommon Case of Esophageal Squamous Cell Carcinoma Metastasizing to the Pancreas and Stomach
At a Glance
| Category | Detail |
| Condition | Esophageal Squamous Cell Carcinoma (ESCC) |
| Key Mechanisms | Aggressive malignancy with high propensity for local invasion and early dissemination. |
| Target Population | Patients with a history of ESCC. |
| Care Setting | Oncology and surgical settings. |
Key Highlights
- Rare metastasis of ESCC to pancreas and stomach.
- Patient underwent radical surgical resection after 37 months disease-free interval.
- Postoperative treatment included immune checkpoint inhibitors and platinum-based chemotherapy.
- Importance of considering rare metastases in differential diagnosis.
- Aggressive surgical resection may be a viable treatment strategy.
Guideline-Based Recommendations
Diagnosis
- Consider imaging studies for new pancreatic lesions in ESCC patients.
Management
- Multidisciplinary approach including surgical resection and systemic therapy.
Monitoring & Follow-up
- Regular imaging surveillance post-treatment for early detection of metastases.
Risks
- Potential for distant metastasis even after prolonged disease-free intervals.
Patient & Prescribing Data
62-year-old male with a history of ESCC and significant comorbidities.
Combination of immune checkpoint inhibitors with platinum-based chemotherapy post-surgery.
Clinical Best Practices
- Conduct thorough imaging for patients with ESCC presenting new abdominal symptoms.
- Utilize a multidisciplinary team for treatment planning in complex cases.
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