Association of serum growth differentiation factor 11 with asthma severity, inflammation, and airway remodeling in pediatric patients - Scorecard - MDSpire
Clinical Scorecard: Relationship Between Serum Growth Differentiation Factor 11 Levels and Asthma Severity, Inflammatory Responses, and Airway Remodeling in Children
At a Glance
Category
Detail
Condition
Asthma
Key Mechanisms
Involvement of GDF11 in inflammation and airway remodeling.
Target Population
Children with asthma.
Care Setting
Pediatric outpatient clinic.
Key Highlights
Lower serum GDF11 levels in children with asthma compared to healthy controls.
GDF11 levels further reduced during asthma exacerbations.
Higher GDF11 levels associated with reduced odds of exacerbation.
Positive correlation between GDF11 and pulmonary function parameters.
GDF11 distinguished asthma exacerbation with good diagnostic accuracy.
Guideline-Based Recommendations
Diagnosis
Asthma diagnosed based on clinical symptoms and variable expiratory airflow limitation.
Management
No regular maintenance therapy was administered at the time of enrollment.
Monitoring & Follow-up
Serum GDF11 levels may serve as a potential biomarker for asthma severity.
Risks
Reduced GDF11 levels associated with increased airway inflammation and remodeling.
Patient & Prescribing Data
107 children with asthma (72 stable, 35 acute exacerbations).
Participants were not receiving asthma-specific treatment at enrollment.
Clinical Best Practices
Consider monitoring serum GDF11 levels in pediatric asthma patients.
Evaluate GDF11 as a potential biomarker for asthma exacerbation risk.
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