Impact of frailty on post-procedural adverse outcomes in older adults aged ≥75 years undergoing percutaneous coronary intervention: a systematic review of observational studies

Category	Detail
Condition	Frailty in elderly patients undergoing PCI
Key Mechanisms	Increased vulnerability to stressors and reduced physiological reserve
Target Population	Patients aged ≥75 years undergoing PCI
Care Setting	Cardiology, specifically for percutaneous coronary intervention

Frail patients aged ≥75 years have a significantly higher risk of in-hospital and all-cause mortality post-PCI.
Frailty is associated with increased risks of bleeding and stroke following PCI.
The prevalence of frailty in patients aged ≥75 years is approximately 33.2%.
The evidence quality for outcomes related to frailty is rated as low according to the GRADE system.
Shared decision-making and individualized management are recommended for frail patients undergoing PCI.

Assess frailty using validated tools such as the Fried Frailty Phenotype or Clinical Frailty Scale.

Monitor for complications such as bleeding and stroke in frail patients post-PCI.

Increased risk of in-hospital mortality (RR = 3.16) and all-cause mortality (RR = 2.51) in frail patients.

Elderly patients aged ≥75 years undergoing PCI.

Frailty significantly impacts treatment outcomes and necessitates careful consideration in treatment planning.

Utilize frailty assessments to guide treatment decisions.
Engage in shared decision-making with patients and families regarding PCI risks and benefits.
Consider individualized management strategies for frail patients.

Clinical Scorecard: The Influence of Frailty on Adverse Outcomes Following Percutaneous Coronary Intervention in Patients Aged 75 and Older: A Systematic Review of Observational Studies