Higher Framingham steatosis index is associated with prevalent breast cancer in women: cross-sectional evidence from NHANES 1999–2018 and an exploratory hospital-based dataset - Scorecard - MDSpire
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Higher Framingham steatosis index is associated with prevalent breast cancer in women: cross-sectional evidence from NHANES 1999–2018 and an exploratory hospital-based dataset
Clinical Scorecard: Association of Elevated Framingham Steatosis Index with Existing Breast Cancer in Women: Insights from NHANES 1999–2018 and a Supplementary Hospital Dataset
At a Glance
Category
Detail
Condition
Breast Cancer
Key Mechanisms
Association of Framingham Steatosis Index (FSI) with metabolic dysfunction and hepatic steatosis-related phenotypes.
Target Population
Adult women aged 18 years or older.
Care Setting
Cross-sectional analysis using NHANES data.
Key Highlights
2.5% of women in NHANES reported a history of breast cancer.
Each 1-unit increase in FSI was associated with higher odds of prevalent breast cancer (OR 1.10).
Association was attenuated after adjustment for age (OR 1.02).
Higher FSI quartiles correlated with greater odds of prevalent breast cancer.
FSI should be interpreted as a composite marker of metabolic-hepatic burden.
Guideline-Based Recommendations
Diagnosis
Breast cancer status determined through standardized NHANES questionnaire data.
Management
FSI should be considered in the context of broader metabolic dysfunction rather than as a direct diagnostic measure.
Monitoring & Follow-up
Regular assessment of metabolic components associated with FSI.
Risks
Higher FSI may indicate increased risk for prevalent breast cancer.
Patient & Prescribing Data
Women with complete metabolic biomarker data from NHANES.
FSI is a composite index and should be interpreted with caution regarding its implications for breast cancer risk.
Clinical Best Practices
Utilize FSI as a non-invasive surrogate marker for hepatic steatosis in assessing breast cancer risk.
Consider age and other metabolic factors when interpreting FSI results.
