Weight Loss, Comorbidity, and Complications After Single-anastomosis Sleeve Ileal Bypass (SASI): A Systematic Review and Meta-analysis - Scorecard - MDSpire

Weight Loss, Comorbidity, and Complications After Single-anastomosis Sleeve Ileal Bypass (SASI): A Systematic Review and Meta-analysis

  • By

  • Helene Marie Haug

  • Hilde Risstad

  • Rolf Eikeland Hagen

  • Tom Mala

  • Jon Adalsteinn Kristinsson

  • Torgeir Thorson Søvik

  • June 24, 2026

  • 0 min

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Clinical Scorecard: Outcomes of Weight Reduction, Comorbid Conditions, and Complications Following Single-Anastomosis Sleeve Ileal Bypass: A Comprehensive Review and Meta-Analysis

At a Glance

CategoryDetail
ConditionObesity and related metabolic disorders
Key MechanismsSingle-anastomosis sleeve ileal bypass (SASI) technique aims to achieve weight loss while minimizing malabsorption risks.
Target PopulationAdults with obesity grade II with serious obesity-related health problems or obesity grade III.
Care SettingMetabolic bariatric surgery (MBS) procedures

Key Highlights

  • SASI shows potential for substantial weight loss and metabolic improvements.
  • Initial studies indicate outcomes comparable to established bariatric procedures.
  • Concerns exist regarding risks of protein-calorie malnutrition and long-term effects.
  • SASI allows for preservation of endoscopic access to the gastrointestinal tract.
  • Reversal of SASI to sleeve gastrectomy is relatively straightforward in adverse cases.

Guideline-Based Recommendations

Diagnosis

  • Evaluate obesity grade and related health problems for surgical intervention eligibility.

Management

  • Consider SASI as a surgical option for eligible patients with obesity.

Monitoring & Follow-up

  • Monitor nutritional status postoperatively, including levels of albumin, hemoglobin, ferritin, vitamin D, and vitamin B12.

Risks

  • Be aware of potential complications including nutritional deficiencies and malnutrition.

Patient & Prescribing Data

Adults with obesity grade II or III and related health issues.

SASI is an investigational procedure with emerging evidence on its effectiveness.

Clinical Best Practices

  • Adhere to eligibility criteria for surgical interventions.
  • Conduct long-term follow-up to assess outcomes and complications.
  • Utilize the GRADE approach to evaluate the quality of evidence in studies.

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