Trained immunity as a systemic bridge: the liver-gut-immune-oral axis in the comorbidity of chronic liver disease and periodontitis - Scorecard - MDSpire

Trained immunity as a systemic bridge: the liver-gut-immune-oral axis in the comorbidity of chronic liver disease and periodontitis

  • By

  • Xiang Li

  • Guodong Lv

  • Daolang Yuan

  • Jun Hu

  • Wenrong Lou

  • Yulin Tu

  • Jing Zhou

  • Rong Qin

  • June 4, 2026

  • 0 min

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Clinical Scorecard: The Role of Trained Immunity in Linking Chronic Liver Disease and Periodontitis through the Liver-Gut-Immune-Oral Axis

At a Glance

CategoryDetail
Condition
Key Mechanisms
Target Population
Care Setting

Key Highlights

  • Trained immunity allows innate immune cells to acquire long-term functional memory.
  • Chronic liver diseases and periodontitis coexist and mutually exacerbate each other.
  • The 'Liver-Gut-Immune-Oral Axis' serves as a conceptual framework linking these conditions.
  • Metabolic reprogramming and epigenetic remodeling are central to trained immunity.
  • Targeting trained immunity may offer strategies for precision medicine in inflammatory diseases.

Guideline-Based Recommendations

Diagnosis

    Management

      Monitoring & Follow-up

        Risks

          Patient & Prescribing Data

          Clinical Best Practices

            Related Resources & Content

            Original Source(s)

            Trained immunity as a systemic bridge: the liver-gut-immune-oral axis in the comorbidity of chronic liver disease and periodontitis

            • by Xiang Li, Guodong Lv, Daolang Yuan, Jun Hu, Wenrong Lou, Yulin Tu, Jing Zhou, Rong Qin

            • June 4, 2026

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