Initiation of an emergency department discharge pathway for low-risk patients with venous thromboembolism: Factors impact real-world practice - Scorecard - MDSpire

Initiation of an emergency department discharge pathway for low-risk patients with venous thromboembolism: Factors impact real-world practice

  • By

  • William B Stubblefield

  • James Barclay

  • Jesse O Wrenn

  • Doug Conway

  • Scott Nelson

  • Quinn S Wells

  • Dario Giuse

  • Zhao Zuo

  • Alexandra M Baird

  • Tyler Barrett

  • Shi Huang

  • Karen Beauchamp

  • Alan B Storrow

  • Sean P Collins

  • Joshua A Beckman

  • July 6, 2026

  • 0 min

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Clinical Scorecard: Implementation of a Discharge Protocol for Low-Risk Venous Thromboembolism Patients in Emergency Departments: Influencing Factors on Practical Application

At a Glance

CategoryDetail
ConditionVenous thromboembolism (VTE)
Key MechanismsRisk stratification tools and direct oral anticoagulants (DOACs) facilitate outpatient treatment.
Target PopulationAdults (age ⩾ 18 years) presenting with VTE in the emergency department.
Care SettingEmergency department

Key Highlights

  • VTE is the third most common cardiovascular disorder with an annual incidence of one in 1000 persons.
  • Approximately 30–50% of patients with PE may be low risk and safe for discharge.
  • The pathway for outpatient treatment was implemented on July 1, 2016.
  • A natural language processing tool was developed to accurately identify VTE diagnoses.
  • The study evaluated patient characteristics and outcomes before and after pathway initiation.

Guideline-Based Recommendations

Diagnosis

  • Use validated decision rules such as the Pulmonary Embolism Severity Index (PESI).
  • Employ natural language processing tools for accurate diagnosis identification.

Management

  • Implement a comprehensive outpatient treatment pathway for low-risk VTE patients.
  • Provide anticoagulation education and a 30-day DOAC prescription.

Monitoring & Follow-up

  • Schedule a 1-week follow-up with an outpatient provider in a vascular medicine clinic.

Risks

  • Monitor for major bleeding events as defined by ISTH criteria within 30 days of ED presentation.

Patient & Prescribing Data

Low-risk VTE patients identified in the emergency department.

Direct oral anticoagulants (DOACs) are used for outpatient management.

Clinical Best Practices

  • Standardize risk stratification processes in emergency departments.
  • Facilitate timely specialty follow-up for patients discharged with VTE.

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