Case Report: Ectopic pancreas mimicking gastrointestinal subepithelial tumors: diagnostic challenges in two surgically confirmed sibling cases - Scorecard - MDSpire

Clinical Report: Ectopic Pancreas Resembling Subepithelial Tumors in the Gastrointestinal Tract: Diagnostic Difficulties in Two Sibling Cases Confirmed by Surgery

  • By

  • Xiaoxia Li

  • Juanxian Gu

  • Xianghua Zhou

  • Liangliang Wang

  • Saiqi Zhang

  • Xiao Huang

  • July 17, 2026

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Clinical Scorecard: Clinical Report: Ectopic Pancreas Resembling Subepithelial Tumors in the Gastrointestinal Tract: Diagnostic Difficulties in Two Sibling Cases Confirmed by Surgery

At a Glance

CategoryDetail
ConditionEctopic pancreas
Key MechanismsCongenital developmental anomaly of pancreatic tissue outside normal anatomical site.
Target PopulationIndividuals with gastrointestinal lesions, particularly asymptomatic patients or those with abdominal pain.
Care SettingGastroenterology and surgical settings.

Key Highlights

  • Ectopic pancreas can mimic gastrointestinal subepithelial tumors, particularly GIST.
  • Histopathological examination is essential for definitive diagnosis.
  • Both cases presented with lesions that were initially suspected to be GIST.
  • Asymptomatic cases may be detected incidentally during routine health check-ups.
  • Long-term recurrence and postoperative complications require further assessment.

Guideline-Based Recommendations

Diagnosis

  • Consider differential diagnoses including GIST, neuroendocrine tumors, and other mesenchymal tumors.
  • Utilize multimodal imaging techniques such as CT and endoscopic ultrasonography.

Management

  • Surgical resection is indicated for symptomatic cases or when malignancy cannot be excluded.

Monitoring & Follow-up

  • Follow-up for recurrence and symptom control post-surgery.

Risks

  • Potential for misdiagnosis as neoplastic lesions due to nonspecific imaging features.

Patient & Prescribing Data

Biological sisters with confirmed ectopic pancreas.

Surgical intervention was performed in both cases with histopathological confirmation.

Clinical Best Practices

  • Histopathological confirmation is crucial for accurate diagnosis of ectopic pancreas.
  • Awareness of the condition's presentation to avoid misdiagnosis.

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