Editorial: Exploring molecular mechanisms in cancer through tumor molecular pathology
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By
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Wenbo Ma
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Haifeng Zhang
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Nianli Liu
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Caiyue Li
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May 26, 2026
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Clinical Scorecard: Investigating Cancer Molecular Mechanisms via Tumor Molecular Pathology
At a Glance
| Category | Detail |
|---|
| Condition | Cancer |
| Key Mechanisms | Integration of histopathological assessment with genomic, transcriptomic, proteomic, immunological, and functional analyses. |
| Target Population | Patients with various types of cancer. |
| Care Setting | Clinical oncology and research settings. |
Key Highlights
- Molecular pathology aids in understanding cancer initiation, progression, and therapeutic response.
- Research Topic includes 19 articles covering various aspects of tumor molecular pathology.
- Focus on actionable alterations for targeted therapy and immunotherapy.
- Clinical application of molecular diagnostics and biomarker discovery is emphasized.
- Integration of molecular profiling with clinical decision-making is crucial.
Guideline-Based Recommendations
Diagnosis
- Utilize molecular diagnostics for improved prognostic assessment.
Management
- Incorporate molecular profiling into treatment selection and optimization.
Monitoring & Follow-up
- Monitor biomarkers such as PRSS22 and CEA for relapse prediction.
Risks
- Identify rare molecular subsets with implications for treatment interpretation.
Patient & Prescribing Data
Patients with various cancer types, including colorectal, ovarian, and lung cancer.
Targeted therapies based on molecular alterations can improve outcomes.
Clinical Best Practices
- Integrate molecular pathology findings with clinical decision-making.
- Use patient-derived models to guide mutation-based therapeutic strategies.
- Employ comprehensive molecular profiling for prognostic stratification.
Related Resources & Content
