Association between leptin gene polymorphisms and hematological metabolic parameters in obese Saudi adults
By
Lamiaa Hamad Al-Jamea
Alexander Woodman
Rehab Yusuf Al-Ansari
Fatimah Salem Alayidh
Khalid Khalaf Alharbi
Nayef Saleh Al Ahmadi
Rashid Al-Jawair
Ibrahim Sahin
Shouq Saleh AlGhamdi
Emad Johar Al Johar
Jenifer Vecina Quiambao
Abdel Halim Deifalla
Yousef Mohammed Hawsawi
June 5, 2026
Clinical Scorecard: Link between genetic variations in the leptin gene and blood metabolic factors in obese adults from Saudi Arabia
At a Glance
Category Detail
Condition Obesity Key Mechanisms Genetic variants in the leptin gene (LEP) associated with hematological changes. Target Population Obese and non-obese Saudi adults. Care Setting Clinical research setting.
Key Highlights
Obesity prevalence in Saudi Arabia exceeds 24.7%. Obese subjects show significant alterations in hematological parameters. Two LEP variants identified: NM_00230.2:c.-39G > A and c.280G > A. Variant NM_00230.2:c.-39G > A associated with obesity risk and elevated white blood cell counts. Hematological changes progress across obesity classes. Guideline-Based Recommendations
Diagnosis
Comprehensive hematological profiling for obese individuals. Management
Consider genetic analysis of leptin gene variants in obesity assessment. Monitoring & Follow-up
Monitor hematological parameters in obese patients. Risks
Increased risk of comorbidities such as type 2 diabetes and cardiovascular diseases. Patient & Prescribing Data
Saudi adults, both obese and non-obese.
Genetic predisposition may influence obesity-related hematological changes.
Clinical Best Practices
Incorporate genetic testing for leptin gene variants in obesity management. Regular monitoring of hematological parameters in obese patients. Related Resources & Content
