Low dose naltrexone for fibromyalgia: case series demonstrating pain relief and other health benefits
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By
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Adrienne Junek
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Mya Anderson
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July 2, 2026
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Clinical Scorecard: Efficacy of Low Dose Naltrexone in Fibromyalgia: A Case Series Highlighting Pain Management and Additional Health Improvements
At a Glance
| Category | Detail |
|---|
| Condition | Fibromyalgia |
| Key Mechanisms | Involves central sensitization and potential modulation of opioid signaling and neuroinflammation. |
| Target Population | Patients diagnosed with fibromyalgia, primarily women. |
| Care Setting | Primary care and integrative medicine clinics. |
Key Highlights
- 8 out of 10 patients reported substantial pain relief with LDN.
- Additional health benefits included improved quality of life and reduced pain flares.
- Common side effects included increased pain, vivid dreams, insomnia, and irritability.
- LDN was well tolerated overall despite some patients discontinuing due to side effects.
- The study supports the consideration of LDN as a treatment option for fibromyalgia.
Guideline-Based Recommendations
Diagnosis
- Fibromyalgia is diagnosed using the American College of Rheumatology criteria.
Management
- Consider off-label use of low dose naltrexone for pain management in fibromyalgia.
Monitoring & Follow-up
- Monitor for pain relief and side effects during LDN treatment.
Risks
- Potential side effects include increased pain, altered sleep, and vivid dreaming.
Patient & Prescribing Data
Patients with fibromyalgia at integrative health clinics.
LDN was often prescribed first-line due to patient preference.
Clinical Best Practices
- Consider slow dose titration of LDN for optimal patient response.
- Engage in discussions about risks and benefits of treatment options with patients.
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