Comparative Analysis of Nerve Block Techniques Utilizing Liposomal Bupivacaine for Postoperative Pain Management in Patients Undergoing Uniportal Video-Assisted Thoracoscopic Lung Resection
By
Ying Zhang
Dongke Liang
Guofeng Liu
Yangsi Huang
Haiping Zhong
Nuo Yang
Yu Zhong
Yanhua Chen
June 17, 2026
Clinical Scorecard: Comparative Analysis of Nerve Block Techniques Utilizing Liposomal Bupivacaine for Postoperative Pain Management in Patients Undergoing Uniportal Video-Assisted Thoracoscopic Lung Resection
At a Glance
Category Detail
Condition Postoperative pain management in lung resection surgery Key Mechanisms Liposomal bupivacaine administered via thoracic paravertebral blockade (TPVB) or intercostal nerve blockade (INB) Target Population Patients undergoing uniportal video-assisted thoracoscopic surgery (VATS) for partial lung resection Care Setting Single-center, parallel-group, randomized controlled trial
Key Highlights
No significant differences in VAS scores between TPVB and INB groups at 6, 24, 48, or 72 hours postoperatively Both techniques showed low pain scores throughout the 72-hour period No significant differences in opioid consumption or need for rescue analgesia between groups Long-term NRS scores for chest pain were similar at 1, 3, and 6 months postoperatively Study registered with the Chinese Clinical Trial Registry (ChiCTR2300075637) Guideline-Based Recommendations
Diagnosis
Assess postoperative pain using Visual Analog Scale (VAS) scores Management
Utilize liposomal bupivacaine for regional anesthesia in thoracoscopic surgeries Monitoring & Follow-up
Monitor pain scores and opioid consumption postoperatively Risks
Consider potential complications from nerve blocks and opioid use Patient & Prescribing Data
Elective surgery patients aged 18–70 years undergoing uniportal VATS
Liposomal bupivacaine provides prolonged analgesia but does not demonstrate superiority over traditional techniques in this study
Clinical Best Practices
Employ ultrasound guidance for TPVB to enhance accuracy Consider patient-specific factors when choosing between TPVB and INB Implement multimodal analgesia strategies to optimize pain management Related Resources & Content
