The role of protein lactylation in skin diseases: from molecular mechanisms to potential therapeutics
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By
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Yue Zhang
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Zhinan Shi
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Xiaohui Mo
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Qiang Ju
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Zhanyan Pan
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July 1, 2026
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Clinical Scorecard: The significance of protein lactylation in dermatological conditions: exploring molecular pathways and therapeutic possibilities
At a Glance
| Category | Detail |
|---|
| Condition | Lactylation in skin diseases |
| Key Mechanisms | Post-translational modification linking metabolism to epigenetic regulation |
| Target Population | Patients with immune-inflammatory skin diseases, pathologic scars, skin malignancies, and skin ageing |
| Care Setting | Dermatological research and clinical applications |
Key Highlights
- Lactylation regulates gene transcription and protein function.
- It plays a role in the pathogenesis of psoriasis, atopic dermatitis, and melanoma.
- Lactate serves as a significant energy source and regulatory factor in biological processes.
- Lactylation may emerge as a novel therapeutic target for skin disorders.
- Current research highlights the need for further investigation into lactylation's role in skin diseases.
Guideline-Based Recommendations
Diagnosis
- Consider lactylation as a potential factor in skin disease pathogenesis.
Management
- Explore lactylation-related inhibitors as therapeutic options.
Monitoring & Follow-up
- Investigate the effects of lactylation on disease progression and treatment response.
Risks
- Potential implications of metabolic dysregulation on skin health.
Patient & Prescribing Data
Individuals with dermatological conditions linked to metabolic dysregulation.
Lactylation-targeted therapies may offer new treatment avenues.
Clinical Best Practices
- Integrate metabolic assessments in the evaluation of skin diseases.
- Stay updated on emerging research regarding lactylation and its implications.
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