PAHR: Prognostic Marker in Severe Aortic Stenosis? - Scorecard - MDSpire
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PAHR: Prognostic Marker in Severe Aortic Stenosis?

Researchers evaluated whether a composite measure of heart rate and pressure could capture overall hemodynamic burden.

  • By

  • Julia Cipriano, MS, CMPP

  • June 27, 2026

  • 3 min

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Clinical Scorecard: PAHR: Prognostic Marker in Severe Aortic Stenosis?

At a Glance

CategoryDetail
ConditionSevere Aortic Stenosis
Key MechanismsPressure-adjusted heart rate (PAHR) integrates chronotropic response, venous congestion, and systemic pressure.
Target PopulationAdult patients with severe native aortic stenosis identified on transthoracic echocardiography.
Care SettingCardiovascular medicine and echocardiography.

Key Highlights

  • Higher PAHR values are associated with poorer survival in severe aortic stenosis.
  • PAHR may identify higher-risk patients under medical management and post-aortic valve replacement.
  • The study included 14,409 patients with severe aortic stenosis.
  • Patients in higher PAHR quartiles had significantly increased risks of mortality.
  • PAHR may provide complementary insight into patient risk before and after valve replacement.

Guideline-Based Recommendations

Diagnosis

  • Severe AS defined by an aortic valve area of 1 cm² or less or an indexed aortic valve area of 0.6 cm²/m² or less.

Management

  • Consider PAHR for risk stratification in patients with severe aortic stenosis.

Monitoring & Follow-up

  • PAHR may inform closer surveillance and earlier evaluation for intervention.

Risks

  • Higher PAHR quartiles are associated with increased mortality risk.

Patient & Prescribing Data

Adult patients with severe native aortic stenosis.

PAHR should be viewed as complementary to existing approaches and requires further validation.

Clinical Best Practices

  • Utilize PAHR as a noninvasive estimate of hemodynamic burden in severe AS.
  • Incorporate PAHR assessment into routine echocardiography and vital sign evaluations.

Related Resources & Content

Original Source(s)

PAHR: Prognostic Marker in Severe Aortic Stenosis?

  • by Julia Cipriano, MS, CMPP

  • June 27, 2026

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