The association between systemic immune-inflammation index and post-stroke depression: a meta-analysis
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By
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Wendi Zhang
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Geng Chang
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Zhen Mu
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June 5, 2026
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Clinical Scorecard: Linking the Systemic Immune-Inflammation Index to Post-Stroke Depression: A Meta-Analytical Review
At a Glance
| Category | Detail |
|---|
| Condition | Post-Stroke Depression (PSD) |
| Key Mechanisms | Systemic inflammation and immune dysregulation |
| Target Population | Adult stroke patients |
| Care Setting | Clinical settings involving stroke management |
Key Highlights
- Elevated systemic immune-inflammation index (SII) is associated with increased risk of PSD.
- High SII at admission correlates with approximately twofold increased risk of PSD (OR = 2.14).
- The association between SII and PSD is consistent across various study designs and populations.
Guideline-Based Recommendations
Diagnosis
- Use standardized diagnostic criteria (DSM or ICD) for diagnosing PSD.
Management
- Consider SII as a potential biomarker for early identification of patients at risk for PSD.
Monitoring & Follow-up
- Monitor SII levels in stroke patients to assess risk for developing PSD.
Risks
- Recognize that PSD is associated with impaired recovery and increased healthcare utilization.
Patient & Prescribing Data
Adult patients with confirmed stroke diagnosis (ischemic, hemorrhagic, or mixed types).
SII may serve as a simple and accessible inflammatory biomarker for early intervention.
Clinical Best Practices
- Incorporate SII measurement in routine assessments for stroke patients.
- Utilize validated depression rating scales for PSD assessment.
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