Association of triglyceride glucose index with cardiovascular autonomic neuropathy in type 2 diabetes mellitus
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By
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Feijuan Kong
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Ziqi Wang
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Qiyu Yang
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Jingzhu Wu
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Shanshan Tang
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Mingyu Gu
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Xiaoying Ding
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Yufan Wang
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July 9, 2026
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Clinical Scorecard: Relationship Between Triglyceride-Glucose Index and Cardiovascular Autonomic Neuropathy in Patients with Type 2 Diabetes Mellitus
At a Glance
| Category | Detail |
|---|
| Condition | Cardiovascular Autonomic Neuropathy (CAN) |
| Key Mechanisms | Impaired autonomic control of the cardiovascular system linked to insulin resistance. |
| Target Population | Patients with Type 2 Diabetes Mellitus (T2DM). |
| Care Setting | Department of Endocrinology and Metabolism, Shanghai General Hospital. |
Key Highlights
- Prevalence of CAN in the study cohort was 61.3%.
- Higher TyG index observed in patients with CAN compared to those without.
- TyG index positively correlates with CART parameters and inversely with HRV indices.
- TyG index is an independent predictor of CAN after adjusting for confounders.
- ROC analysis shows TyG index has an AUC of 0.854 for CAN.
Guideline-Based Recommendations
Diagnosis
- Use cardiovascular autonomic reflex test (CART) and heart rate variability (HRV) measurements for CAN assessment.
Management
- Monitor TyG index as a potential marker for CAN in T2DM patients.
Monitoring & Follow-up
- Regular assessment of cardiovascular autonomic function in patients with T2DM.
Risks
- Patients with CAN face a threefold higher risk of cardiovascular morbidity and mortality.
Patient & Prescribing Data
Hospitalized patients with Type 2 Diabetes Mellitus.
TyG index may serve as a practical marker for assessing risk of CAN.
Clinical Best Practices
- Early detection of CAN is critical for halting disease progression.
- Utilize TyG index for point-of-care testing in diabetes-related complications.
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