1q25.3–q32.1 deletion causing multisystem developmental delay: a case report and literature review
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By
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Lifang Liu
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Rong Yu
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Weizhong Zhang
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Shiwen Huang
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Taiwei Huang
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June 10, 2026
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Clinical Scorecard: Deletion of 1q25.3–q32.1 Associated with Multisystem Developmental Delays: A Case Study and Review of Existing Literature
At a Glance
| Category | Detail |
|---|
| Condition | |
| Key Mechanisms | |
| Target Population | Pediatric patients (newborn to 18 years) with suspected chromosomal abnormalities. |
| Care Setting | |
Key Highlights
- Literature review identified 31 cases of 1q25–q32 deletion syndrome, highlighting the rarity and variability of clinical presentations.
Guideline-Based Recommendations
Diagnosis
Management
- Implement individualized intervention, including physical therapy and speech therapy, and long-term follow-up.
Monitoring & Follow-up
Risks
Patient & Prescribing Data
Early intervention, including physical and occupational therapy, may improve developmental outcomes.
Clinical Best Practices
- Involve a multidisciplinary team, including pediatricians, geneticists, and therapists, for comprehensive management.
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