Malignant breast adenomyoepithelioma with diagnostic discordance: a case report and literature review
By
Jing-Jou Lo
Lu-Pei Pan
Ming-Feng Hou
Hidenobu Takahashi
July 8, 2026
Clinical Scorecard: A Case Study and Literature Review of Malignant Adenomyoepithelioma in the Breast with Diagnostic Challenges
At a Glance
Category Detail
Condition Malignant Adenomyoepithelioma (MAME) of the breast Key Mechanisms Biphasic neoplasm with potential for local recurrence and distant metastasis; diagnosis relies on histopathologic assessment and immunohistochemistry. Target Population Patients with breast masses, particularly older women. Care Setting Oncology and surgical settings for breast cancer management.
Key Highlights
MAME is a rare biphasic tumor with malignant potential. Preoperative diagnosis often mischaracterizes MAME as invasive carcinoma of no special type. Negative-margin resection is crucial for management. Adjuvant chemotherapy and radiotherapy are individualized due to limited evidence. Histologic-subtype discordance presents a diagnostic challenge. Guideline-Based Recommendations
Diagnosis
Histopathologic assessment with immunohistochemistry is essential for confirming MAME. Management
Complete surgical excision with negative margins is the cornerstone of treatment. Monitoring & Follow-up
Prolonged surveillance is recommended to detect late relapse or distant metastasis. Risks
Local recurrence and distant metastasis are potential risks associated with MAME. Patient & Prescribing Data
Older women presenting with breast masses.
Adjuvant capecitabine chemotherapy and whole-breast irradiation were utilized in the reported case.
Clinical Best Practices
Consider sentinel lymph node biopsy when lymphatic spread is suspected. Utilize intraoperative radiotherapy as a boost in selected cases. Related Resources & Content
