Natural supplements in breast cancer therapy: translational evidence, clinical safety, and emerging challenges
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By
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Sirajunisa Talath
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Mohamed El-Tanani
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Adil Farooq Wali
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Syed Arman Rabbani
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Bhoomendra Bhongande
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Walaa Ibraheem
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Ashot Avagimyan
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Karolina Hoffmann
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Ioannis Ilias
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Sorina Ispas
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Maggio Viviana
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Anna Paczkowska
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Manfredi Rizzo
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April 30, 2026
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Clinical Scorecard: Complementary Natural Supplements in Breast Cancer Treatment: Evidence from Research, Safety Considerations, and New Challenges
At a Glance
| Category | Detail |
|---|
| Condition | Breast Cancer |
| Key Mechanisms | Antioxidants, anti-inflammatory agents, apoptotic inductors, hormonal modulators |
| Target Population | Women diagnosed with breast cancer |
| Care Setting | Oncology clinics and integrative medicine settings |
Key Highlights
- Breast cancer is the most frequent cancer among women globally.
- Natural supplements may modulate therapeutic response and influence treatment-related toxicity.
- Robust clinical evidence for the efficacy of natural supplements remains limited.
- Standardization and bioavailability issues hinder clinical translation.
- Future studies should focus on dosing personalization and integration with precision oncology.
Guideline-Based Recommendations
Diagnosis
- Consider molecular and genetic variability among breast cancer subtypes.
Management
- Integrate natural supplements with conventional therapies cautiously.
Monitoring & Follow-up
- Establish pharmacovigilance systems for natural supplement use.
Risks
- Be aware of potential herb-drug interactions and safety concerns.
Patient & Prescribing Data
Women with varying subtypes of breast cancer, including HR-positive, HER2-enriched, and TNBC.
Natural supplements may provide additional benefits but require careful consideration of safety and efficacy.
Clinical Best Practices
- Promote interdisciplinary collaboration among clinicians, pharmacologists, and traditional medicine scientists.
- Adhere to evidence-based practices when incorporating natural supplements.
References
