Characteristics of Human Metapneumovirus Infection Compared to Respiratory Syncytial Virus and Influenza Infections in Adults Hospitalized for Influenza-Like Illness in France, 2012–2022 - Scorecard - MDSpire
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Characteristics of Human Metapneumovirus Infection Compared to Respiratory Syncytial Virus and Influenza Infections in Adults Hospitalized for Influenza-Like Illness in France, 2012–2022
Clinical Scorecard: Comparative Analysis of Human Metapneumovirus, Respiratory Syncytial Virus, and Influenza Infections in Adults Admitted for Influenza-Like Illness in France from 2012 to 2022
At a Glance
Category
Detail
Condition
Human metapneumovirus (hMPV), Influenza A and B virus (FLUV), Respiratory syncytial virus (RSV) infections
Key Mechanisms
Respiratory viral infections causing influenza-like illness with potential complications including acute heart failure and pneumonia
Target Population
Adults hospitalized with community-acquired influenza-like illness
Care Setting
Hospital inpatient setting in French referral hospitals
Key Highlights
hMPV infection in hospitalized adults is associated with higher rates of complications, especially acute heart failure, compared to influenza.
The frequency of respiratory and cardiac complications in hMPV infection is similar to that observed in RSV infection.
In-hospital all-cause mortality rates are comparable among hMPV, FLUV, and RSV infections (~4-5%).
Guideline-Based Recommendations
Diagnosis
Use multiplex reverse-transcription polymerase chain reaction (RT-PCR) on nasopharyngeal swabs to detect hMPV, FLUV, RSV, and other respiratory viruses.
Screen patients hospitalized with influenza-like illness during influenza circulation periods and year-round during the COVID-19 pandemic.
Management
Monitor for complications such as acute heart failure and respiratory complications in patients with hMPV infection.
Consider patient age and presence of multiple chronic conditions when managing hMPV infections.
No specific antiviral therapies or vaccines for hMPV are currently available; supportive care remains the mainstay.
Monitoring & Follow-up
Closely observe hospitalized patients with hMPV for development of cardiac and pulmonary complications during hospital stay.
Track clinical outcomes including complication rates and in-hospital mortality.
Risks
Older adults with multiple chronic conditions are at increased risk of complications from hMPV infection.
Acute heart failure occurs twice as frequently in hMPV-infected patients compared to influenza-infected patients.
Patient & Prescribing Data
Adults hospitalized with influenza-like illness testing positive for hMPV, FLUV, or RSV
No specific antiviral treatments for hMPV are currently approved; management focuses on supportive care and monitoring for complications. Influenza vaccination status was considered but no direct treatment data for hMPV antivirals were reported.
Clinical Best Practices
Perform comprehensive viral testing in adults hospitalized with influenza-like illness to identify causative pathogens including hMPV.
Recognize that hMPV infection can lead to significant cardiac complications, necessitating cardiac monitoring.
Apply stratified analysis by season to account for variability in viral circulation and incidence.
Exclude coinfections in analyses to accurately assess outcomes attributable to single viral infections.
by Paul Loubet, Salomé Guitton, Simon Rolland, Louise H Lefrancois, Liem Binh Luong Nguyen, Philippe Vanhems, Fabrice Laine, Florence Galtier, Xavier Duval, Bruno Lina, Martine Valette, Giséle Lagathu, Vincent Foulongne, Nadira Houhou-Fidhou, Anne Sophie L’Honneur, Fabrice Carrat, Laurence Meyer, Christine Durier, Odile Launay, for the FLUVAC Study Group
