Personalized management of glucokinase-related monogenic diabetes (GCK-MODY) during pregnancy: a case report
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By
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Ana Filipa Bolas
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João Oliveira Torres
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Paula Bogalho
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José Silva-Nunes
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May 28, 2026
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Clinical Scorecard: Tailored Approach to Managing Glucokinase-Related Monogenic Diabetes (GCK-MODY) in Pregnancy: A Case Study
At a Glance
| Category | Detail |
|---|
| Condition | |
| Key Mechanisms | Heterozygous inactivating variants in the GCK gene lead to mild hyperglycemia by raising the glucose threshold for insulin secretion. |
| Target Population | |
| Care Setting | |
Key Highlights
Guideline-Based Recommendations
Diagnosis
- Consider genetic testing for GCK gene variants in patients with a family history of diabetes.
Management
- Individualize glycemic targets during pregnancy based on the absence of fetal genotyping.
Monitoring & Follow-up
- Use continuous glucose monitoring (CGM) to guide insulin therapy adjustments.
Risks
- Potential for maternal hypoglycemia and fetal overexposure to maternal hyperglycemia.
Patient & Prescribing Data
Pregnant women with GCK-MODY and a variant of uncertain significance.
Insulin therapy was initiated with basal insulin and intensified to a basal-bolus regimen.
Clinical Best Practices
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