Early Changes in Creatinine Levels Predict Outcomes in Patients with Sepsis
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By
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Dan Liu
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Zhonglin Zhang
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Aihua Qin
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Xiaofeng Li
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Jian Zhao
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Huihua Jiang
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Yi Zhao
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Yuanzhuo Chen
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Hu Peng
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February 19, 2026
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Clinical Scorecard: Early Changes in Creatinine Levels Predict Outcomes in Patients with Sepsis
At a Glance
| Category | Detail |
|---|
| Condition | Sepsis |
| Key Mechanisms | Dysregulated host response to infection leading to systemic inflammation and organ failure. |
| Target Population | Patients diagnosed with sepsis according to Sepsis 3.0 criteria. |
| Care Setting | Intensive Care Unit (ICU) |
Key Highlights
- Serum creatinine levels are linked to renal function and can predict adverse outcomes in sepsis patients.
- The study analyzed 8663 ICU septic patients using data from the MIMIC-IV database.
- Latent class trajectory models (LCTM) were employed to identify creatinine change trajectories.
Guideline-Based Recommendations
Diagnosis
- Utilize Sepsis 3.0 criteria for diagnosing sepsis.
Management
- Monitor serum creatinine levels to assess renal function and predict mortality.
Monitoring & Follow-up
- Track creatinine levels continuously over the first 72 hours of ICU admission.
Risks
- Patients with elevated creatinine levels are at higher risk for 28-day mortality.
Patient & Prescribing Data
ICU patients diagnosed with sepsis, excluding those with chronic kidney disease.
Early intervention based on creatinine trajectories may improve outcomes.
Clinical Best Practices
- Implement routine monitoring of renal function in septic patients.
- Utilize LCTM for analyzing longitudinal data to identify high-risk groups.
References
