Efficacy and Safety of a Topical Skincare Regimen with Tripeptide/Hexapeptide following Aesthetic Procedures: Analysis of Two Randomized, Split-Face Trials in Asian Subjects - Scorecard - MDSpire

Efficacy and Safety of a Topical Skincare Regimen with Tripeptide/Hexapeptide following Aesthetic Procedures: Analysis of Two Randomized, Split-Face Trials in Asian Subjects

  • By

  • Zhenfeng Liu

  • Zhen Yi

  • Peng Wang

  • Li Wan

  • Li Ye

  • Yijing Chen

  • Yiping Zhong

  • Mengting Qiu

  • Linshan Wu

  • Li Fan

  • Xiaoyan Fu

  • Alan D. Widgerow

  • Yuanmeng Yang

  • Céline Blanché

  • Bin Yang

  • June 20, 2026

  • 0 min

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Clinical Scorecard: Effectiveness and Safety of a Tripeptide/Hexapeptide-Based Topical Skincare Routine After Aesthetic Treatments: Findings from Two Randomized, Split-Face Studies in Asian Participants

At a Glance

CategoryDetail
ConditionSkin recovery after aesthetic treatments
Key MechanismsTriHex Technology® supports extracellular matrix remodeling through peptide action.
Target PopulationAsian participants aged 18-70 with Fitzpatrick skin type II–IV.
Care SettingClinical aesthetic procedures involving fractional CO2 laser and radiofrequency microneedling.

Key Highlights

  • Serum-treated side showed significantly greater recovery on multiple parameters.
  • High subject satisfaction reported with the serum.
  • Benefits observed across multiple time points.
  • Further controlled studies are warranted.

Guideline-Based Recommendations

Diagnosis

  • Assess skin recovery needs post-energy-based device treatments.

Management

  • Utilize TriHex Technology® serum for enhanced recovery after FCL and RFMN.

Monitoring & Follow-up

  • Evaluate skin recovery and satisfaction at multiple time points.

Risks

  • Monitor for postinflammatory hyperpigmentation in Asian skin.

Patient & Prescribing Data

Asian individuals undergoing aesthetic procedures.

TriHex Technology® may mitigate downtime and enhance recovery.

Clinical Best Practices

  • Implement optimal periprocedural skincare to support barrier repair.
  • Consider patient skin type and recovery needs when selecting treatments.

Related Resources & Content

Original Source(s)

Efficacy and Safety of a Topical Skincare Regimen with Tripeptide/Hexapeptide following Aesthetic Procedures: Analysis of Two Randomized, Split-Face Trials in Asian Subjects

  • by Zhenfeng Liu, Zhen Yi, Peng Wang, Li Wan, Li Ye, Yijing Chen, Yiping Zhong, Mengting Qiu, Linshan Wu, Li Fan, Xiaoyan Fu, Alan D. Widgerow, Yuanmeng Yang, Céline Blanché, Bin Yang

  • June 20, 2026

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