Age- and sex-based risk stratification in takotsubo syndrome: a Japanese nationwide registry study
By
Tomohiro Hayashi
Kazuaki Negishi
Takato Kobayashi
Koshiro Kanaoka
Hozuka Akita
Yuto Shinkura
Ryo Nishio
Kensuke Matsumoto
Masahiko Hoshijima
Satoru Kawasaki
Hogara Nishisaki
Masanobu Okayama
Tsuneaki Kenzaka
July 1, 2026
Clinical Scorecard: Risk Assessment in Takotsubo Syndrome Based on Age and Gender: Insights from a Nationwide Japanese Registry Analysis
At a Glance
Category Detail
Condition Takotsubo Syndrome Key Mechanisms Acute but reversible cardiac dysfunction triggered by emotional or physical stress. Target Population Patients with Takotsubo syndrome, particularly older adults and males. Care Setting Nationwide Japanese Registry of All Cardiac and Vascular Diseases
Key Highlights
Older age and male sex are independent predictors of in-hospital mortality in TTS. In-hospital mortality rates increase with age and are higher in men compared to women. The study analyzed data from 13,585 patients with TTS across 1,141 hospitals in Japan. Guideline-Based Recommendations
Diagnosis
Diagnosis based on the Mayo Clinic diagnostic criteria and ICD-10 codes. Management
In-hospital management includes intensive care and monitoring for comorbidities. Monitoring & Follow-up
Clinical monitoring should consider age and sex as significant factors. Risks
Older age and male sex are associated with higher in-hospital mortality. Patient & Prescribing Data
Patients hospitalized with their first episode of Takotsubo syndrome.
Evidence-based treatments remain lacking due to poor understanding of TTS pathophysiology.
Clinical Best Practices
Utilize age and sex-specific assessments for risk evaluation in TTS patients. Monitor for comorbidities, particularly in male patients. Related Resources & Content
