Oral HRS-7535 Lowered A1c in Trial - Scorecard - MDSpire

Oral HRS-7535 Lowered A1c in Trial

Nonpeptide oral agent requires no fasting administration.

  • By

  • Kathryn Wighton

  • June 5, 2026

  • 9 min

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Clinical Scorecard: Oral HRS-7535 Lowered A1c in Trial

At a Glance

CategoryDetail
ConditionType 2 Diabetes
Key MechanismsNonpeptide glucagon-like peptide-1 receptor agonist (GLP-1 RA)
Target PopulationPatients aged 18 to 75 years with inadequately controlled type 2 diabetes on metformin
Care SettingPhase 2 randomized controlled trial across 44 centers in China

Key Highlights

  • HRS-7535 reduced hemoglobin A1c levels compared to placebo after 16 weeks.
  • Patients achieved hemoglobin A1c levels below 7.0% ranged from 49% to 63% in HRS-7535 groups versus 15% in placebo.
  • Gastrointestinal adverse events were the most common treatment-related events, predominantly mild or moderate.

Guideline-Based Recommendations

Diagnosis

  • Eligible patients had hemoglobin A1c levels of 7.5% to 11.0%.

Management

  • HRS-7535 was administered once daily at doses of 15 mg, 30 mg, 60 mg, or 90 mg.

Monitoring & Follow-up

  • Monitor hemoglobin A1c levels and gastrointestinal adverse events.

Risks

  • Gastrointestinal adverse events occurred in 72% to 85% of patients receiving HRS-7535.

Patient & Prescribing Data

194 patients aged 18 to 75 years with type 2 diabetes inadequately controlled with metformin.

Rescue antihyperglycemic therapy was required in 3% to 8% of patients receiving HRS-7535 compared to 31% in placebo.

Clinical Best Practices

  • Consider the patient's body mass index and demographics when interpreting trial results.
  • Titrate doses carefully to manage gastrointestinal tolerability.

Related Resources & Content

Original Source(s)

Oral HRS-7535 Lowered A1c in Trial

  • by Kathryn Wighton

  • June 5, 2026

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