Mechanisms of Steroid Impact on Eye Health and Disease: Therapeutic Benefits, Side Effects, and Stress-Related Influencers - A Comprehensive Literature Review

Category	Detail
Condition	Ocular health and disease
Key Mechanisms	Neuroendocrine dysregulation, glucocorticoid signaling, intraocular pressure regulation, inflammatory signaling
Target Population	Patients with ocular disorders influenced by stress and glucocorticoid therapy
Care Setting	Ophthalmic care

Stress-related neuroendocrine dysregulation linked to ocular disorders such as glaucoma and ocular surface disease.
Glucocorticoids are essential for managing inflammatory and immune-mediated ocular diseases.
Prolonged glucocorticoid use may lead to adverse effects including ocular hypertension and cataract formation.
Chronobiological factors may influence treatment efficacy and safety in ocular therapy.
Psychosocial stress impacts treatment adherence and quality of life in patients with chronic ocular conditions.

Optimize glucocorticoid therapy based on individual patient susceptibility and disease type.

Regularly monitor for adverse effects of glucocorticoid therapy, including intraocular pressure.

Be aware of risks such as delayed wound healing and increased infection susceptibility with glucocorticoid use.

Individuals with inflammatory and immune-mediated ocular disorders.

Personalized treatment approaches are recommended to minimize complications from glucocorticoid therapy.

Integrate psychosocial assessments into ophthalmic care.
Utilize advanced corticosteroid delivery systems to enhance therapeutic outcomes.
Adopt a multidisciplinary approach to manage ocular health effectively.