Clinical Scorecard: Neighborhood Socioeconomic Disparities and Their Impact on Glioblastoma Patient Outcomes: Findings from a Single-Center Cohort Analysis
At a Glance
Category
Detail
Condition
Glioblastoma
Key Mechanisms
Neighborhood-level socioeconomic disadvantage measured by Area Deprivation Index (ADI) influences overall survival and treatment disparities in glioblastoma patients.
Target Population
Adult patients (≥18 years) with histopathologically confirmed glioblastoma
Care Setting
Single tertiary care center with retrospective cohort analysis
Key Highlights
Higher neighborhood deprivation (top ADI quartile) is associated with worse overall survival in glioblastoma patients.
Patients from high deprivation neighborhoods are more likely to be Black, have Medicaid/Medicare insurance, live farther from treatment centers, and reside in rural areas.
High deprivation patients undergo complete surgical resection less frequently despite similar comorbidity burden.
Guideline-Based Recommendations
Diagnosis
Incorporate neighborhood-level socioeconomic status assessment using Area Deprivation Index (ADI) to identify patients at risk for poorer outcomes.
Management
Address disparities in surgical resection rates and access to chemotherapy and radiotherapy among patients from socioeconomically deprived neighborhoods.
Consider targeted interventions to improve timely and comprehensive treatment delivery in high deprivation populations.
Monitoring & Follow-up
Monitor treatment adherence and outcomes with attention to socioeconomic and geographic factors influencing care access.
Risks
Increased risk of suboptimal surgical resection and potentially delayed or reduced access to standard therapies in patients from high deprivation neighborhoods.
Patient & Prescribing Data
1464 adult glioblastoma patients treated between 2008 and 2023
84% received radiotherapy, 83% received chemotherapy, and 46% underwent complete resection; patients from high deprivation areas had lower rates of complete resection.
Clinical Best Practices
Utilize Area Deprivation Index (ADI) for neighborhood-level socioeconomic assessment in glioblastoma patients.
Implement strategies to mitigate socioeconomic and geographic barriers to complete surgical resection and adjuvant therapies.
Incorporate multidisciplinary care coordination to address disparities linked to race, insurance status, and rural residence.
