Attaining sustainability in inflammatory bowel disease
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By
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Olga Maria Nardone
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Beatriz Gros
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Tommaso Lorenzo Parigi
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Aimen Farooq
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Lumir Kunovsky
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Shaji Sebastian
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November 19, 2025
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Clinical Scorecard: Achieving Long-Term Sustainability in the Management of Inflammatory Bowel Disease
At a Glance
| Category | Detail |
| Condition | Inflammatory Bowel Disease (IBD), including Crohn’s disease and ulcerative colitis |
| Key Mechanisms | Treat-to-target strategies, biologics, small molecules, proactive monitoring, therapeutic drug monitoring, and integrated care pathways |
| Target Population | Patients with IBD globally, including those in newly industrialized and low-resource countries |
| Care Setting | Multidisciplinary healthcare systems with outpatient clinics, endoscopy units, and imaging services |
Key Highlights
- IBD prevalence is rising worldwide, increasing pressure on healthcare systems and resources.
- Sustainable IBD care balances clinical effectiveness with affordability, equity, and environmental responsibility.
- Climate change impacts IBD development and exacerbations; healthcare contributes significantly to carbon emissions.
Guideline-Based Recommendations
Diagnosis
- Use validated biomarkers and imaging modalities (colonoscopy, CT, MRI, intestinal ultrasound) for proactive monitoring.
- Adopt essential diagnostics that are context-appropriate and resource-efficient.
Management
- Implement treat-to-target strategies aiming for steroid-free remission and prevention of cumulative bowel damage.
- Optimize biologic and small-molecule therapies including therapeutic drug monitoring.
- De-implement low-value practices and avoid clinical inertia in active disease.
- Promote strong care coordination and support transitions between pediatric and adult services.
- Integrate patient-reported outcomes into decision-making to enhance engagement and self-management.
Monitoring & Follow-up
- Intensify monitoring demands with efficient use of biomarkers and imaging to balance clinical benefits and resource use.
- Adopt telemedicine and green endoscopy practices to reduce environmental footprint.
Risks
- Stringent targets may increase treatment burden, costs, and adverse effects.
- Healthcare delivery contributes significantly to carbon emissions and environmental waste.
- Limited access to advanced therapies and diagnostics may widen inequities in care quality and outcomes.
Patient & Prescribing Data
IBD patients across diverse healthcare settings including low-resource regions
Responsible adoption of biosimilars and rational sequencing of therapies can improve sustainability and access.
Clinical Best Practices
- Balance clinical effectiveness with feasibility, affordability, and environmental sustainability.
- Build scalable, context-appropriate care models that reduce unwarranted variation.
- Coordinate multidisciplinary teams to optimize resource use and patient outcomes.
- Incorporate environmental impact considerations into clinical decision-making.
- Use telemedicine and reduce reliance on single-use materials to lower carbon footprint.
References