Current status and research hotspots of pediatric nephrotic syndrome: a bibliometric analysis (2011–2025)
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By
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Wenyin Yang
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Yu Pei
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Chaoyang Wang
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Mingxia Tang
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Jiadong Xie
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Jing Zhao
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July 9, 2026
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Clinical Scorecard: Pediatric Nephrotic Syndrome: A Bibliometric Review of Current Trends and Research Focuses (2011–2025)
At a Glance
| Category | Detail |
| Condition | Pediatric Nephrotic Syndrome |
| Key Mechanisms | Immune dysregulation, circulating factors, podocyte dysfunction |
| Target Population | Children with nephrotic syndrome |
| Care Setting | Pediatric nephrology research |
Key Highlights
- Total of 2,873 publications analyzed from 2011 to 2025
- China contributed the most articles (452 publications)
- Key topics include nephrotic syndrome, children, and focal segmental glomerulosclerosis
- Emerging keywords include leukocyte count and lipoid nephrosis
- Assistance Publique Hopitaux Paris had the highest number of publications (77)
Guideline-Based Recommendations
Diagnosis
- Characterized by massive proteinuria (>3.5 g/24 h), hypoalbuminemia, hyperlipidemia, and edema
Management
- Advancements in immunosuppressive regimens and biological agents such as Rituximab
Monitoring & Follow-up
Risks
- Frequent relapses and long-term complications of treatment
Patient & Prescribing Data
Children diagnosed with nephrotic syndrome
Focus on novel immunosuppressants and understanding pathogenic mechanisms
Clinical Best Practices
- Utilize bibliometric analysis for evaluating research trends
- Collaborate globally to optimize management strategies
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