GLP-1 receptor agonists and psychiatric outcomes: a bibliometric analysis of research trends, thematic evolution, and collaboration networks - Scorecard - MDSpire

Analysis of Research Trends and Collaborative Networks in GLP-1 Receptor Agonists and Their Impact on Psychiatric Outcomes

  • By

  • Maria Meritxell Roca Mora

  • Marcia Sanchez-Monge

  • Dibe Balardini Ayoub

  • Ana Beatriz P. Aguiar-Barros

  • Sofia Serrano-Porras

  • Renato de Filippis

  • Georgios Schoretsanitis

  • July 21, 2026

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Clinical Scorecard: Analysis of Research Trends and Collaborative Networks in GLP-1 Receptor Agonists and Their Impact on Psychiatric Outcomes

At a Glance

CategoryDetail
ConditionGLP-1 Receptor Agonists and Psychiatric Outcomes
Key MechanismsGLP-1 RAs enhance glucose-dependent insulin secretion, suppress glucagon release, and promote satiety, with effects on psychiatric outcomes linked to GLP-1 receptor expression in the central nervous system.
Target PopulationIndividuals with type 2 diabetes mellitus and obesity, with a focus on psychiatric outcomes such as depression and anxiety.
Care SettingResearch and clinical studies evaluating GLP-1 RAs in relation to psychiatric health.

Key Highlights

  • Exponential growth in publications from fewer than 10 in 2004 to nearly 500 in 2025.
  • Thematic mapping identified depression as a niche theme in GLP-1 RA research.
  • Research spans 1,063 journals and 9,269 authors across 85 countries.
  • Large-scale studies indicate reduced risks of psychiatric disorders among GLP-1 RA users.
  • Emerging focus on bridging cardiometabolic trials with psychiatric endpoints.

Guideline-Based Recommendations

Diagnosis

    Management

      Monitoring & Follow-up

        Risks

          Patient & Prescribing Data

          Patients with type 2 diabetes and obesity, particularly those experiencing psychiatric conditions.

          GLP-1 RAs may have beneficial effects on psychiatric outcomes, necessitating further research.

          Clinical Best Practices

          • Conduct large cardiometabolic trials with psychiatric co-primary endpoints.
          • Utilize bibliometric analysis to identify research trends and gaps in GLP-1 RA literature.

          Related Resources & Content

            Original Source(s)

            GLP-1 receptor agonists and psychiatric outcomes: a bibliometric analysis of research trends, thematic evolution, and collaboration networks

            • by Maria Meritxell Roca Mora, Marcia Sanchez-Monge, Dibe Balardini Ayoub, Ana Beatriz P. Aguiar-Barros, Sofia Serrano-Porras, Renato de Filippis, Georgios Schoretsanitis

            • July 21, 2026

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