Single-cell extracellular vesicle-program scoring maps immunometabolic rewiring and immune crosstalk of mesenchymal stromal cells in intervertebral disc degeneration, prioritizing AP2S1 and CSTB - Scorecard - MDSpire

Single-cell extracellular vesicle-program scoring maps immunometabolic rewiring and immune crosstalk of mesenchymal stromal cells in intervertebral disc degeneration, prioritizing AP2S1 and CSTB

  • By

  • Fengyu Ma

  • Kelv Shen

  • Ziqiang Wu

  • Hanshi Yang

  • Mingzhe Yu

  • Zhendong Huang

  • Fengxuan Han

  • Zhengfeng Lu

  • May 22, 2026

  • 0 min

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Clinical Scorecard: Single-Cell Scoring of Extracellular Vesicle Programs Reveals Immunometabolic Changes and Immune Interactions in Mesenchymal Stromal Cells During Intervertebral Disc Degeneration, Highlighting AP2S1 and CSTB

At a Glance

CategoryDetail
Condition
Key MechanismsRefine to explicitly mention the role of immune signaling and metabolic stress as interconnected processes.
Target Population
Care Setting

Key Highlights

  • AUC

Guideline-Based Recommendations

Diagnosis

    Management

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    Monitoring & Follow-up

      Risks

        Patient & Prescribing Data

        Elaborate on how MSC-EVs impact patient recovery and inflammation.

        Clinical Best Practices

        • best_practices

        Related Resources & Content

        Original Source(s)

        Single-cell extracellular vesicle-program scoring maps immunometabolic rewiring and immune crosstalk of mesenchymal stromal cells in intervertebral disc degeneration, prioritizing AP2S1 and CSTB

        • by Fengyu Ma, Kelv Shen, Ziqiang Wu, Hanshi Yang, Mingzhe Yu, Zhendong Huang, Fengxuan Han, Zhengfeng Lu

        • May 22, 2026

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