Assessment of Macular, Peripapillary, and Choroidal Thickness Along with Minimum Rim Width in Patients with Clinically Unilateral Pseudoexfoliation Syndrome: A Cross-Sectional Study Utilizing the Glaucoma Module of Spectralis SD-OCT - Scorecard - MDSpire
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Assessment of Macular, Peripapillary, and Choroidal Thickness Along with Minimum Rim Width in Patients with Clinically Unilateral Pseudoexfoliation Syndrome: A Cross-Sectional Study Utilizing the Glaucoma Module of Spectralis SD-OCT

  • By

  • Büşra Yılmaz Tuğan

  • Gözde Karaca

  • Nurşen Yüksel

  • February 9, 2026

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Clinical Scorecard: Assessment of Macular, Peripapillary, and Choroidal Thickness Along with Minimum Rim Width in Patients with Clinically Unilateral Pseudoexfoliation Syndrome: A Cross-Sectional Study Utilizing the Glaucoma Module of Spectralis SD-OCT

At a Glance

CategoryDetail
ConditionPseudoexfoliation Syndrome (PEXS)
Key MechanismsAccumulation of fibrillar extracellular material leading to trabecular cell dysfunction and increased intraocular pressure.
Target PopulationPatients with clinically unilateral PEXS and healthy controls.
Care SettingOphthalmology Department at a university hospital.

Key Highlights

  • PEXS is often asymmetric and can lead to open-angle glaucoma.
  • The study assessed retinal layer thickness in unilateral PEXS patients.
  • Identifiable changes in retinal structure may indicate disease progression.
  • Advanced imaging techniques allow for detailed analysis of retinal layers.
  • PEXS is associated with systemic conditions including vascular and neurological disorders.

Guideline-Based Recommendations

Diagnosis

  • Use slit-lamp biomicroscopy to detect PEXS.
  • Assess intraocular pressure and optic nerve head alterations.

Management

  • Monitor for signs of glaucoma development in PEXS patients.
  • Consider systemic health implications in PEXS management.

Monitoring & Follow-up

  • Regular OCT imaging to evaluate retinal layer thickness and changes.

Risks

  • Increased risk of glaucoma and potential systemic health issues.

Patient & Prescribing Data

Unilateral PEXS patients aged 50-85 years.

No antiglaucoma medication required if IOP is below 21 mmHg.

Clinical Best Practices

  • Conduct comprehensive ophthalmic assessments including visual acuity and tonometry.
  • Utilize SD-OCT for detailed imaging of retinal layers.
  • Ensure proper patient selection based on exclusion criteria.

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