Differential Analysis of Homocysteine and Uric Acid Levels in Patients with Cognitive Impairment Due to Parkinson’s Disease and Post-Stroke Conditions

Category	Detail
Condition	Cognitive Impairment due to Parkinson’s Disease and Post-Stroke Conditions
Key Mechanisms	Elevated homocysteine levels and low uric acid levels are associated with cognitive impairment in PD-CI, while PS-CI shows different metabolic profiles.
Target Population	Patients aged 40–85 years with cognitive impairment due to PD or post-stroke conditions.
Care Setting	Department of Neurology at Yangjiang Hospital of Traditional Chinese Medicine

PD-CI patients exhibited significantly higher homocysteine levels compared to PS-CI patients.
Uric acid levels were significantly lower in PD-CI patients than in PS-CI patients.
Homocysteine negatively correlated with cognitive function as measured by MMSE, particularly in PD-CI patients.
Low educational attainment and lower uric acid levels were independently associated with PD-CI.
Findings suggest distinct metabolic profiles between PD-CI and PS-CI.

Utilize Mini-Mental State Examination (MMSE) for cognitive function assessment.
Consider homocysteine and uric acid levels in differential diagnosis of cognitive impairment.

Focus on metabolic profiles for personalized interventions in cognitive impairment.

Patients with cognitive impairment due to Parkinson’s disease and post-stroke conditions.

Elevated homocysteine levels are a common factor associated with cognitive impairment in both conditions.

Clinical Scorecard: Differential Analysis of Homocysteine and Uric Acid Levels in Patients with Cognitive Impairment Due to Parkinson’s Disease and Post-Stroke Conditions